Results 51 to 60 of about 10,615 (164)

Sea Lice (Lepeophtheirus salmonis) Harbour Putative Fish Pathogens: Insights From Illumina and Nanopore Sequencing

Journal of Fish Diseases, EarlyView.
ABSTRACT Ectoparasites that penetrate host skin can act as biological or mechanical vectors for pathogens and, in some cases, serve as reservoirs. Crustacean ectoparasites of fish are potential vectors of pathogens, which is especially relevant for obligate pathogens (e.g., Aeromonas salmonicida) with limited seawater survival. Sea lice (Lepeophtheirus
B. Klimesova, N. M. Ruane, R. Domingo‐Bretón, F. Moroni, F. Naya‐Català, J. Pérez‐Sánchez, K. O'Dwyer, O. Lyashevska, H. Rodger, A. Talbot   +9 more
wiley   +1 more source

Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

Molecules, 2022
The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen, Emmanuelle Girard-Valenciennes, Axelle Septembre-Malaterre, Philippe Gasque, Pascale Guiraud, Jimmy Sélambarom   +5 more
doaj   +1 more source

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Emergence of Salmonid Alphavirus Genotype 2 in Norway—Molecular Characterization of Viral Strains Circulating in Norway and Scotland

Viruses, 2021
Pancreas disease (PD) and sleeping disease (SD), caused by an alphavirus, are endemic in European salmonid aquaculture, causing significant mortality, reduced growth and poor flesh quality. In 2010, a new variant of salmonid alphavirus emerged in Norway,
Monika J. Hjortaas, Elena Fringuelli, Adérito L. Monjane, Aase B. Mikalsen, Christine M. Jonassen, Paul Savage, Hilde Sindre   +6 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

The Poisson CUSUM Chart for Monitoring Small Counts: Addressing the Estimation Uncertainty

Biometrical Journal, Volume 68, Issue 2, April 2026.
ABSTRACT This study addresses the impact of estimating in‐control parameters on the performance of the Poisson cumulative sum (CUSUM) chart in detecting an increase in the mean when the counts are small. To reduce false signals induced by estimation uncertainty, recommendations prescribe impractically large sample sizes or propose methods that widen ...
Stan Heidema, Ivo V. Stoepker, Ralph Huits, Edwin R. van den Heuvel   +3 more
wiley   +1 more source

Macrophage Migration Inhibitory Factor Receptor CD74 Mediates Alphavirus‐Induced Arthritis and Myositis in Murine Models of Alphavirus Infection [PDF]

Arthritis & Rheumatism, 2013
ObjectiveArthrogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) circulate worldwide. This virus class causes debilitating illnesses that are characterized by arthritis, arthralgia, and myalgia. In previous studies, we identified macrophage migration inhibitory factor (MIF) as a critical inflammatory factor in the ...
Herrero, Lara J, Sheng, Kuo-Ching, Jian, Peng, Taylor, Adam, Her, Zhisheng, Herring, Belinda L, Chow, Angela, Leo, Yee-Sin, Hickey, Michael J, Morand, Eric F, Ng, Lisa FP, Bucala, Richard, Mahalingam, Suresh   +12 more
openaire   +3 more sources

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.

PLoS Pathogens
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan   +9 more
doaj   +1 more source