Results 51 to 60 of about 12,278 (197)

Current Understanding of the Role of Cholesterol in the Life Cycle of Alphaviruses

Viruses, 2020
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family ...
Ivanildo P. Sousa, Carlos A. M. Carvalho, Andre M. O. Gomes   +2 more
doaj   +1 more source

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

PLoS Pathogens, 2023
Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert   +6 more
doaj   +1 more source

Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells [PDF]

, 2011
Background: Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian ...
Geertsema, C (Corinne), Corinne Geertsema, van Oers, MM, Paulina Andrade, Heldens, J.G.M., Geertsema, C., Vlak Just M, Pijlman Gorben P, Andrade, Paulina, Vlak, J.M. (Just), Vlak, J.M., Pijlman, G.P. (Gorben), Just M Vlak, Metz Stefan W, Goldbach, RW, Metz, S.W. (Stefan), Martina, B.E.E. (Byron), Geertsema Corinne, Metz, S.W.H., Stefan W Metz, Jacco G Heldens, Geertsema, C. (Corinne), Heldens Jacco G, Martina, Byron, Andrade, P. (Paulina), Metz, SW, Andrade Paulina, Heldens, J., Rob W Goldbach, Pijlman, G.P., Pijlman, GP, van Oers Monique M, Oers, M.M. (Monique) van, van Oers, M.M., Andrade, P, Goldbach, R.W., Gorben P Pijlman, Monique M van Oers, Vlak, JM, Goldbach Rob W, Heldens, JG, Byron E Martina, Martina, Byron E., Martina Byron E, Oers, M.M., van   +44 more
core   +1 more source

Early Events in Alphavirus Replication Determine the Outcome of Infection [PDF]

Journal of Virology, 2012
ABSTRACT Alphaviruses are a group of important human and animal pathogens. They efficiently replicate to high titers in vivo and in many commonly used cell lines of vertebrate origin. They have also evolved effective means of interfering with development of the innate immune
Ilya, Frolov, Maryna, Akhrymuk, Ivan, Akhrymuk, Svetlana, Atasheva, Elena I, Frolova   +4 more
openaire   +2 more sources

Transcriptomic analysis of the host response to early stage salmonid alphavirus (SAV-1) infection in Atlantic salmon Salmo salar L. [PDF]

, 2012
Salmon pancreas disease, caused by salmonid alphavirus (SAV) of the family Togaviridae, is an economically important disease affecting farmed Atlantic salmon (Salmo salar L.) in Scotland, Norway, and Ireland.
Adams, Alexandra, Richards, Randolph, Thompson, Kimberly, Bron, James, Taggart, John, Ireland, Jacqueline, Herath, Tharangani   +6 more
core   +1 more source

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission. [PDF]

PLoS Pathogens, 2016
Alphaviruses are highly organized enveloped RNA viruses with an internal nucleocapsid surrounded by a membrane containing the E2 and E1 transmembrane proteins.
Maria Guadalupe Martinez, Margaret Kielian   +1 more
doaj   +1 more source

Impact of Salmonid alphavirus infection in diploid and triploid Atlantic salmon (Salmo salar L.) fry. [PDF]

PLoS One, 2017
With increasing interest in the use of triploid salmon in commercial aquaculture, gaining an understanding of how economically important pathogens affect triploid stocks is important. To compare the susceptibility of diploid and triploid Atlantic salmon (
Herath TK, Ashby AJ, Jayasuriya NS, Bron JE, Taylor JF, Adams A, Richards RH, Weidmann M, Ferguson HW, Taggart JB, Migaud H, Fordyce MJ, Thompson KD.   +12 more
europepmc   +3 more sources

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU)2016/429): Infection with salmonid alphavirus (SAV)

EFSA Journal, 2023
Infection with salmonid alphavirus (SAV) was assessed according to the criteria of the Animal Health Law (AHL), in particular the criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its ...
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Paolo Calistri, Elisabetta Canali, Julian Ashley Drewe, Bruno Garin‐Bastuji, José Luis Gonzales Rojas, Christian Gortázar, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Barbara Padalino, Helen Clare Roberts, Hans Spoolder, Karl Ståhl, Antonio Velarde, Arvo Viltrop, Christoph Winckler, James Bron, Niels Jorgen Olesen, Hilde Sindre, David Stone, Niccolò Vendramin, Sotiria Eleni Antoniou, Alessandro Broglia, Anna Eleonora Karagianni, Alexandra Papanikolaou, Dominique Joseph Bicout   +28 more
doaj   +1 more source

Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]

PLoS Neglected Tropical Diseases, 2010
Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
doaj   +1 more source

Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]

Journal of Virology, 2015
ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
K J, Sokoloski, K C, Haist, T E, Morrison, S, Mukhopadhyay, R W, Hardy   +4 more
openaire   +2 more sources