Results 61 to 70 of about 10,615 (164)

Triple Burden in the Democratic Republic of Congo: Climate Change, Armed Conflict, and the Silent Spread of Arboviruses. A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The Democratic Republic of Congo (DRC) faces a “triple burden” of public health threats which includes climate change, protracted armed conflict, and the under‐recognized spread of arboviral diseases. Arboviruses, such as dengue, chikungunya, Zika, and yellow fever, are transmitted by Aedes aegypti and Aedes albopictus mosquitoes ...
Stanis Donnang, Hermann Yokolo, Dujardin Makeda, Joshua Ekouo, Zubayer Shams, Johan Armel Domga Kaptso, Josias Silatchom Kamgang, Yann Valerin Waffo, Christian Tague   +8 more
wiley   +1 more source

Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells

npj Vaccines, 2021
The precise mechanism by which many virus-based vectors activate immune responses remains unknown. Dendritic cells (DCs) play key roles in priming T cell responses and controlling virus replication, but their functions in generating protective immunity ...
Carolina Chiale, Anthony M. Marchese, Yoichi Furuya, Michael D. Robek   +3 more
doaj   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Development of eNA Sampling for Early Detection of Pathogens in On‐Farm Water Sources

Environmental DNA, Volume 8, Issue 2, March/April 2026.
We compare four water‐sampling methods for detecting microbial and viral eNA in livestock troughs and show all approaches effectively recover community profiles, supporting flexible, field‐ready surveillance of livestock pathogens. ABSTRACT Early detection of livestock pathogens is critical for mitigating risk and implementing timely control or ...
Maxine P. Piggott, Allyson Malpartida
wiley   +1 more source

Borna disease virus infection: Retrospective case series of five horses and two donkeys in Switzerland

Equine Veterinary Education, Volume 38, Issue 3, Page e119-e129, March 2026.
Summary Borna disease is an acute to subacute, rarely chronic non‐purulent meningoencephaylomyelitis affecting mainly horses and sheep. This case series describes the clinical signs, diagnosis, treatment, outcome and post‐mortem findings of five horses and two donkeys with this condition. The equids affected were geldings or mares of various breeds and
I. L. Piotrowski, M. Hilbe, H. K. Junge
wiley   +1 more source

Viral Disease Histopathology in Aquaculture Finfish: Organ‐Specific Pathological Changes and Diagnostic Insights, Referencing the World Organisation for Animal Health: A Review

Reviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT The aquaculture industry faces significant challenges from viral diseases, many of which are listed by the World Organisation for Animal Health (WOAH) as priority pathogens due to their impact on global finfish health and production. This review synthesizes current knowledge on the histopathology of key WOAH‐listed viral pathogens, including ...
Ram Babu Kurapati, Grace Ramena, Humphrey Wanjala, Sharon Gudapati, Yathish Ramena   +4 more
wiley   +1 more source

Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection

Journal of Virology, 2000
ABSTRACT The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420.
T, Ahola, P, Kujala, M, Tuittila, T, Blom, P, Laakkonen, A, Hinkkanen, P, Auvinen   +6 more
openaire   +3 more sources

Variable effects ofWolbachiaon alphavirus infection inAedes aegypti

, 2023
2.AbstractWolbachia pipientis(=Wolbachia) has promise as a tool to suppress virus transmission byAedes aegyptimosquitoes. However,Wolbachiacan have variable effects on mosquito-borne viruses. This variation remains poorly characterized, yet the multimodal effects ofWolbachiaon diverse pathogens could have important implications for public health. Here,
Brittany L. Dodson, Sujit Pujhari, Marco Brustolin, Hillery C. Metz, Jason L. Rasgon   +4 more
openaire   +2 more sources

Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama

Emerging Infectious Diseases
Madariaga virus (MADV) and Venezuelan equine encephalitis virus (VEEV) are emerging arboviruses affecting rural and remote areas of Latin America. However, clinical and epidemiologic reports are limited, and outbreaks are occurring at an increasing ...
Luis Felipe Rivera, Carlos Lezcano-Coba, Josefrancisco Galué, Xacdiel Rodriguez, Yelissa Juarez, William M. de Souza, Zeuz Capitan-Barrios, Anayansi Valderrama, Leyda Abrego, Hector Cedeño, Carmela Jackman, Jesse J. Waggoner, Patricia V. Aguilar, Hilda Guzman, Scott C. Weaver, Robert B. Tesh, Sandra López-Vèrges, Christl A. Donnelly, Cassia F. Estofolete, Mauricio L. Nogueira, Nuno R. Faria, Nikos Vasilakis, Amy Y. Vittor, Darci R. Smith, Jean-Paul Carrera   +24 more
doaj   +1 more source