Results 81 to 90 of about 12,278 (197)
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1167-1179, June 2026.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Greater than the sum of its parts: understanding alphavirus infection through characterization of nonstructural polyproteins [PDF]
, 2016 Alphaviruses are enveloped, positive strand RNA viruses that are capable of causing a variety of symptoms including arthritis, encephalitis, and even death in humans. Chikungunya virus, a member of the alphavirus genus, is a recently emerging pathogen in
core +1 more source
npj Vaccines, 2021 The precise mechanism by which many virus-based vectors activate immune responses remains unknown. Dendritic cells (DCs) play key roles in priming T cell responses and controlling virus replication, but their functions in generating protective immunity ...
Carolina Chiale +3 more
doaj +1 more source
Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat +11 more
wiley +1 more source
Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection
Journal of Virology, 2000 ABSTRACT The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420.
T, Ahola +6 more
openaire +3 more sources
Characterization of an In Vitro Model of Alphavirus Infection of Immature and Mature Neurons [PDF]
Journal of Virology, 2005 ABSTRACT Terminally differentiated, mature neurons are essential cells that are not easily regenerated. Neurotropic viruses, such as Sindbis virus (SV), cause encephalomyelitis through their ability to replicate in neurons. SV causes the death of immature neurons, while mature neurons can often survive infection.
Patty S, Vernon, Diane E, Griffin
openaire +2 more sources
Dengue Virus Capsid Protein Interaction With Nucleic Acids
BioFactors, Volume 52, Issue 3, May/June 2026.Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva +7 more
wiley +1 more source
Alphavirus-host interactions : how to unravel the proviral activity of G3BP [PDF]
, 2019 The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome.
Benjamin Götte (18672085)
core
mSphere, 2018 Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith +10 more
doaj +1 more source
Reviews in Medical Virology, Volume 36, Issue 3, May 2026.ABSTRACT Post‐dengue fatigue syndrome is a debilitating long‐term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post‐dengue depression complicate differentiation.
Anna Condé +6 more
wiley +1 more source