Results 91 to 100 of about 12,278 (197)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Variable effects of Wolbachia on alphavirus infection in Aedes aegypti

, 2023
2. Abstract Wolbachia pipientis (= Wolbachia ) has promise as a tool to suppress virus transmission by Aedes aegypti mosquitoes.
Brittany L. Dodson, Sujit Pujhari, Marco Brustolin, Hillery C. Metz, Jason L. Rasgon   +4 more
openaire   +2 more sources

Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes. [PDF]

, 2013
Current methods for detecting real-time alphavirus (Family Togaviridae) infection in mosquitoes require the use of recombinant viruses engineered to express a visibly detectable reporter protein.
Ken E Olson, J Jordan Steel, Irma Sanchez-Vargas, Brian J Geiss, Alexander W E Franz   +4 more
core   +1 more source

Hunting in the Rainforest and Mayaro Virus Infection: An emerging Alphavirus in Ecuador

Journal of Global Infectious Diseases, 2011
Objectives: The objectives of this report were to document the potential presence of Mayaro virus infection in Ecuador and to examine potential risk factors for Mayaro virus infection among the personnel of a military garrison in the Amazonian rainforest.
Ricardo O Izurieta, Maurizio Macaluso, Douglas M Watts, Robert B Tesh, Bolivar Guerra, Ligia M Cruz, Sagar Galwankar, Sten H Vermund   +7 more
openaire   +3 more sources

Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama

Emerging Infectious Diseases
Madariaga virus (MADV) and Venezuelan equine encephalitis virus (VEEV) are emerging arboviruses affecting rural and remote areas of Latin America. However, clinical and epidemiologic reports are limited, and outbreaks are occurring at an increasing ...
Luis Felipe Rivera, Carlos Lezcano-Coba, Josefrancisco Galué, Xacdiel Rodriguez, Yelissa Juarez, William M. de Souza, Zeuz Capitan-Barrios, Anayansi Valderrama, Leyda Abrego, Hector Cedeño, Carmela Jackman, Jesse J. Waggoner, Patricia V. Aguilar, Hilda Guzman, Scott C. Weaver, Robert B. Tesh, Sandra López-Vèrges, Christl A. Donnelly, Cassia F. Estofolete, Mauricio L. Nogueira, Nuno R. Faria, Nikos Vasilakis, Amy Y. Vittor, Darci R. Smith, Jean-Paul Carrera   +24 more
doaj   +1 more source

Vector‐borne diseases‐knowledge maps

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract This scientific report provides a structured overview of the main characteristics of 25 selected vector‐borne diseases (VBDs) of potential relevance for the EU, including 12 diseases listed under the Animal Health Law (AHL) and 13 non‐listed diseases.
European Food Safety Authority (EFSA), Sofie Dhollander, Ieva Baltusyte, Fabio Bigoni, Alessandro Broglia, Jordi Figuerola, Hans‐Hermann Thulke, Miguel Angel Chueca Miranda   +7 more
wiley   +1 more source

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers [PDF]

, 2008
The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) enter cells readily and can inhibit viral replication ...
Borisevich, Viktoriya, Yun, Nadezhda E., Stein, David A., Seregin, Alexey, Rijnbrand, Rene, Zacks, Michele A., Blouch, Robert, Ma, Yinghong, Iversen, Patrick L., Paessler, Slobodan, Dziuba, Natallia, Ni, Haolin   +11 more
core   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Alphavirus Infection of the CNS: Entry, Dissemination, and Neurodegeneration

European Journal of Molecular & Clinical Medicine, 2015
Alphaviruses most often associated with neuroinvasive disease are limited to the Americas and include strains of EEEV, VEEV, and WEEV. The process of alphavirus entry into the CNS of infected vertebrates following challenge is not well-understood. It is thought that virus entry into the CNS depends on the inoculation route.
Phillips AT, Rico AB, Aboellail TA, Olson KE   +3 more
openaire   +1 more source