Results 271 to 280 of about 27,933 (291)

The Identification and Development of a Novel Oncolytic Virus: Alphavirus M1

Human Gene Therapy, 2020
Oncolytic virotherapy represents an ideal therapeutic platform for cancer in which natural or engineered viruses selectively replicate in and destroy tumor cells, whereas sparing normal cells.
Jing Cai, Guangmei Yan
semanticscholar   +1 more source

An eruption associated with alphavirus infection

British Journal of Dermatology, 1996
Some alphaviruses, e.g. Sindbis, cause an acute febrile illness associated with papular rashes and arthralgia. The diagnosis is usually serological and, hence, the histopathology of the rashes has been poorly elucidated. We report on two patients with rapidly healing eruptions associated with Sindbis virus infection.
P, Autio, K M, Niemi, A L, Kariniemi
openaire   +2 more sources

Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8

Cell, 2023
Ofer Zimmerman, Maxwell I. Zimmerman, S. Raju, Christopher A Nelson, J. Errico, Emily A. Madden, Autumn C Holmes, Ahmed O. Hassan, L. VanBlargan, A. S. Kim, L. Adams, K. Basore, Bradley M. Whitener, Sathvik Palakurty, H. Davis-Adams, Chengqun Sun, Theron Gilliland, J. T. Earnest, Hongming Ma, Gregory D. Ebel, Christian Zmasek, Richard H. Scheuermann, W. Klimstra, D. Fremont, Michael S. Diamond   +24 more
semanticscholar   +1 more source

Alphavirus-Based Antigen Preparation

2020
Alphavirus-based vectors present an efficient approach for antigen preparation applied for vaccine development. Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been engineered for high-level expression of antigens targeting infectious diseases and tumors.
openaire   +2 more sources

The effects of alphavirus infection on neurons

Annals of Neurology, 1994
Sindbis virus is an alphavirus that causes encephalitis in mice. The primary target cells for central nervous system infection are neurons. The outcome of neuronal infection is dependent on the age of the mouse at the time of infection (maturity of the neuron) and the strain of virus used for infection (virulence of the virus).
D E, Griffin, B, Levine, S, Ubol, J M, Hardwick   +3 more
openaire   +2 more sources

Alphavirus Entry into Host Cells

2015
Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic.
Ricardo, Vancini, Raquel, Hernandez, Dennis, Brown   +2 more
openaire   +2 more sources

Alphavirus Hybrid Virion Vaccines

1996
Many members of the alphavirus family are important human or veterinary pathogens. These viruses are extremely similar in molecular architecture yet differ in host range and in the pathological consequences of infection. Despite marked structural conservation, the various species are inefficient in eliciting immunological cross protection. Previously(l)
A, Shafferman, S, Lustig, Y, Inbar, M, Halevy, P, Schneider, T, Bino, M, Leitner, H, Grosfeld, B, Velan, F, Schödel, S, Cohen   +10 more
openaire   +2 more sources

Alphavirus-Based Expression Systems

1996
Alphaviruses are enveloped positive-strand RNA viruses transmitted to vertebrate hosts via mosquito vectors (reviewed in 34). In the last several years, the alphavirus RNA replication and packaging machinery have been exploited for cytoplasmic expression of heterologous RNAs and proteins in animal cells (for reviews see 3, 24, 27).
openaire   +2 more sources

Alphavirus RNA replication in vertebrate cells.

Advances in Virus Research, 2021
T. Ahola, G. McInerney, A. Merits
semanticscholar   +1 more source

The regulation of disassembly of alphavirus cores

Archives of Virology, 2009
Alphaviruses are used as model viruses for structure determination and for analysis of virus entry. They are used also as vectors for protein expression and gene therapy. Virus particles are assembled by budding, using preformed cores and a modified cellular membrane. During entry, alphaviruses release the viral core into the cytoplasm.
openaire   +2 more sources