Results 111 to 120 of about 13,848 (209)

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia

Stem Cell Research
Hypophosphatasia (HPP) is characterized by loss of function variants in the alkaline phosphatase (ALPL) gene that leads to impaired mineralization in bones and teeth.
Abhay Srivastava, Dylan Walker, Jason Uzonna, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +4 more
doaj   +1 more source

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

Utility of Cytochemical and Flow Cytometry Detection of Alkaline Phosphatase for Differential Diagnosis of CD34+ Acute Leukaemia in Canines

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 41-50, March 2026.
ABSTRACT Alkaline phosphatase (ALP) enzymatic activity has been proposed as a marker for distinguishing canine acute leukaemia (AL) subtypes (i.e., myeloid vs. lymphoid). However, ALP enzymatic activity has not been fully evaluated in CD34+ AL. Determine whether ALP enzymatic activity can differentiate CD34+ AL subtypes in dogs and distinguish CD34+ AL
Megan Aalto, Janna Yoshimoto, Jillian Nolan, Kenzie Olsen, Dylan Ammons, Emily Rout, Anne C. Avery, R. Adam Harris   +7 more
wiley   +1 more source

Comprehensive treatment approaches for skeletal deformities in hypophosphatasia: a case study of ALPL gene variants

Frontiers in Pediatrics
This study presents a case report of an 11-year-old boy with hypophosphatasia due to compound heterozygous ALPL gene genetic variants, focusing on the treatment effects of comprehensive approaches for this rare genetic disorder.
Qiongjie Jiao, Guixia Ma, Qian Ni
doaj   +1 more source

Probing Dark Matter with AGN Jets

, 2010
We study the possibility of detecting a signature of particle dark matter in the spectrum of gamma-ray photons from active galactic nuclei (AGNs) resulting from the scattering of high-energy particles in the AGN jet off of dark matter particles.
Gorchtein, Mikhail, Profumo, Stefano, Ubaldi, Lorenzo   +2 more
core   +1 more source

MECP2 Insufficiency Attenuates RUNX2‐Dependent Osteoblast Differentiation via miR‐126‐3p/DKK1‐Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
MECP2 insufficiency leads to upregulation of miR‐126‐3p, which in turn enhances the endogenous Wnt antagonist DKK1. DKK1 inhibits the canonical Wnt signaling pathway, thereby impairing RUNX2‐dependent osteoblast differentiation. ABSTRACT Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by loss‐of‐function mutations in the gene encoding ...
Shuangshan Dong, Lu Wang, Hiroki Kato, Saki Hirofuji, Zhiyan Zhou, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda   +12 more
wiley   +1 more source

Linkage Relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on Porcine Chromosome 6

Genomics, 1993
A five-point linkage map has been established between the loci encoding liver/bone/kidney alkaline phosphatase (ALPL), enolase 1-alpha (ENO1), glucose-phosphate isomerase (GPI), phosphogluconate dehydrogenase (PGD), and transforming growth factor beta 1 (TGFB1) in swine.
P A, Clamp, R, Feltes, D, Shalhevet, J E, Beever, E, Atac, L B, Schook   +5 more
openaire   +2 more sources

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification

Kidney & Blood Pressure Research, 2018
Background/Aims: Hyperphosphatemia promotes medial vascular calcification, at least partly, by induction of osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). The complex signaling pathways regulating this process are still
Beate Boehme, Nadeshda Schelski, Manousos Makridakis, Laura Henze, Antonia Vlahou, Florian Lang, Burkert Pieske, Ioana Alesutan, Jakob Voelkl   +8 more
doaj   +1 more source

Comment on ``Exact three-dimensional wave function and the on-shell t matrix for the sharply cut-off Coulomb potential: Failure of the standard renormalization factor''

, 2009
The solutions analytically derived by Gloeckle et al. [Phys. Rev. C79, 044003 (2009)] for the three-dimensional wave function and on-shell t matrix in the case of scattering on a sharply cut-off Coulomb potential appear to be fallacious.
J. R. Taylor, Konstantin A. Kouzakov, L. D. Faddeev, Vladimir L. Shablov, Yuri V. Popov   +4 more
core   +1 more source

Basic fibroblast growth factor regulates phosphate/pyrophosphate regulatory genes in stem cells isolated from human exfoliated deciduous teeth

Stem Cell Research & Therapy, 2018
Background Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs).
Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster, Thanaphum Osathanon   +4 more
doaj   +1 more source