Results 101 to 110 of about 10,054 (208)

AVICs exposed to cyclic stretch or HOTAIR siRNA have increased expression of ALPL and BMP2.

, 2014
A and B. Human AVICs exposed to 14% stretch for 24 h have increased ALPL and BMP2 mRNA levels, 50% and 77% respectively, as compared to static controls. N = 6. C and D.
Roman Sasik (193092), Katrina Carrion (557998), Gary Hardiman (193097), Vishal Nigam (558002), Jeffrey Dyo (557999), Vishal Patel (558000), Salah A. Mohamed (558001)   +6 more
core   +1 more source

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia

Stem Cell Research
Hypophosphatasia (HPP) is characterized by loss of function variants in the alkaline phosphatase (ALPL) gene that leads to impaired mineralization in bones and teeth.
Abhay Srivastava, Dylan Walker, Jason Uzonna, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +4 more
doaj   +1 more source

Broad Vitamin B6-Related Metabolic Disturbances in a Zebrafish Model of Hypophosphatasia (TNSALP-Deficiency)

Hypophosphatasia (HPP) is a rare inborn error of metabolism caused by pathogenic variants in ALPL, coding for tissue non-specific alkaline phosphatase. HPP patients suffer from impaired bone mineralization, and in severe cases from vitamin B6-responsive ...
Sanne M. C. Savelberg, Judith J. Jans, Nanda M. Verhoeven-Duif, Nils W. F. Meijer, Monique Albersen, Marjolein Bosma, Jolita Ciapaite, Federico Tessadori, Jeroen P. W. Bakkers, Gijs van Haaften   +9 more
core   +2 more sources

AScrFI polymorphism in the human ALPL gene [PDF]

Nucleic Acids Research, 1991
T, Okuyama, N, Matsuo, J, Kudoh, N, Shimizu   +3 more
openaire   +2 more sources

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification

Kidney & Blood Pressure Research, 2018
Background/Aims: Hyperphosphatemia promotes medial vascular calcification, at least partly, by induction of osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). The complex signaling pathways regulating this process are still
Beate Boehme, Nadeshda Schelski, Manousos Makridakis, Laura Henze, Antonia Vlahou, Florian Lang, Burkert Pieske, Ioana Alesutan, Jakob Voelkl   +8 more
doaj   +1 more source

Whole genome sequencing in adults with clinical hallmarks of hypophosphatasia negative for ALPL variants

Background Hypophosphatasia (HPP) is a rare disease caused by deficient activity of tissue-nonspecific alkaline phosphatase (ALP), encoded by the ALPL gene.
Reder, Felix, Petryk, Anna, Seefried, Lothar, Bauer, Peter, del Angel, Guillermo   +4 more
core   +1 more source

Plasma Rich in Growth Factors in Bone Regeneration: The Proximity to the Clot as a Differential Factor in Osteoblast Cell Behaviour

Dentistry Journal
The osteogenic differentiation process, by which bone marrow mesenchymal stem cells and osteoprogenitors transform into osteoblasts, is regulated by several growth factors, cytokines, and hormones.
Eduardo Anitua, Mar Zalduendo, Roberto Tierno, Mohammad Hamdan Alkhraisat   +3 more
doaj   +1 more source

Polyphenol-rich extract from Wisteria floribunda (Willd.) DC. flowers promotes osteoblast differentiation and bone formation by modulating the mTOR pathway

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the osteogenic effects of polyphenol-rich extracts from Wisteria floribunda (Willd.) DC. (W. floribunda) flowers and elucidate the underlying mechanisms. Methods: Polyphenolic compounds of W.
Jayasingha Arachchige Chathuranga Chanaka Jayasingha, Kyoung Tae Lee, Cheng-Yun Jin, Yung Hyun Choi, Chang Soo Lee, Min-Jeong Jung, Gi-Young Kim   +6 more
doaj   +1 more source

Allele polymorphism of alkaline, acid soluble phosphatase genes and vitamin D-binding protein in postmenopausal osteoporosis

Терапевтический архив, 2004
Aim. To study polymorphism of genes involved in mechanisms regulating metabolism of bone tissue: alkaline (ALPL) and acid (ACPI) phosphatases, vitamin D-bindingprotein (GC); to ascertain associations of their genotypes and alleles with osteoporosis (OP ...
M Yu Krylov, T A Korotkova, V A Myakotkin, L I Benevolenskaya   +3 more
doaj  

Alkaline Phosphatases: A Potential Cause of Variability in Therapeutic Response to Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion?

Movement Disorders, Volume 41, Issue 10, Page 2787-2788, October 2026.
Manon Auffret, Marc Vérin
wiley   +1 more source