Results 111 to 120 of about 14,236 (244)

Stability Properties of the Time Domain Electric Field Integral Equation Using a Separable Approximation for the Convolution with the Retarded Potential

, 2011
The state of art of time domain integral equation (TDIE) solvers has grown by leaps and bounds over the past decade. During this time, advances have been made in (i) the development of accelerators that can be retrofitted with these solvers and (ii ...
Nair, N. V., Pray, A. J., Shanker, B.
core   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, Volume 36, Issue 31, 16 April 2026.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investigated how high glucose levels influence BMSC differentiation, proliferation, viability, and metabolism ...
Suzanna Shirazi, Ezaldeen Esawi, Zeyad D. Nassar, Stan Gronthos, Dimitrios Cakouros   +4 more
wiley   +1 more source

The ALPL gene variant project: results of the first 100 reclassified variants

JBMR Plus
Abstract Hypophosphatasia (HPP) is an inherited disorder that affects bone and tooth mineralization, among other body systems. HPP is caused by pathogenic variants in the alkaline phosphatase-liver (ALPL) gene, which encodes tissue nonspecific alkaline phosphatase.
Farman, Mariam R, Malli, Theodora, Rehder, Catherine, Webersinke, Gerald, Rockman-Greenberg, Cheryl, Dahir, Kathryn, Martos-Moreno, Gabriel Ángel, Linglart, Agnès, Ozono, Keiichi, Seefried, Lothar, del Angel, Guillermo, Barbazza, Francesca, Shojaei, Sara, Ebner-Jahn, Jessica, Högler, Florian, Nading, Erica Burner, Huggins, Erin, Rush, Eric T, El-Gazzar, Ahmed, Tauer, Josephine T, Kishnani, Priya S, Högler, Wolfgang   +21 more
openaire   +3 more sources

Application of Intracellular Vesicles Surpass Extracellular Vesicles in Regenerative Repair of Inflammatory Bone Defects via the LAMA4‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Periodontitis‐induced inflammatory microenvironment compromises the function of periodontal ligament stem cells (PDLSCs) and significantly impedes the regeneration of periodontal tissues. Meanwhile, the clinical application of extracellular vesicles (EVs) is constrained by their low yield and high production costs.
Haotian Liu, Yu Wu, Qunyi Wang, Ting Zhang, Xin Tong, Fuhua Yan, Qian Zhang   +6 more
wiley   +1 more source

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia

Stem Cell Research
Hypophosphatasia (HPP) is characterized by loss of function variants in the alkaline phosphatase (ALPL) gene that leads to impaired mineralization in bones and teeth.
Abhay Srivastava, Dylan Walker, Jason Uzonna, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +4 more
doaj   +1 more source

The Alkaline Phosphatase (ALPL) Locus Is Associated with B6 Vitamer Levels in CSF and Plasma [PDF]

, 2018
Loes M. Olde Loohuis, Monique Albersen, Simone de Jong, Timothy Wu, Jurjen J. Luykx, Judith Jans, Nanda M. Verhoeven‐Duif, Roel A. Ophoff   +7 more
openalex   +1 more source

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif, MD Nazmul Hasan, Nobuhiro Nozaki, Yutaro Ide, Yoshiyuki Akiyama, Shaohsu Wang, Most Shumi Akhter Shathi, Osamu Yamato, Naoki Miura   +8 more
wiley   +1 more source

Comprehensive treatment approaches for skeletal deformities in hypophosphatasia: a case study of ALPL gene variants

Frontiers in Pediatrics
This study presents a case report of an 11-year-old boy with hypophosphatasia due to compound heterozygous ALPL gene genetic variants, focusing on the treatment effects of comprehensive approaches for this rare genetic disorder.
Qiongjie Jiao, Guixia Ma, Qian Ni
doaj   +1 more source