Results 81 to 90 of about 14,236 (244)

Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair, Kevin Carratu, Natalie E. Rintoul, Holly L. Hedrick, William H. Peranteau, Catherine M. Avitabile, Kirsty McWalter, Paul Kruszka, Ian D. Krantz, K. Taylor Wild   +9 more
wiley   +1 more source

Titanium nanotubes activate genes related to bone formation in vitro

Dental Research Journal, 2012
Background: Titanium is used worldwide to make osseointegrable devices, thanks to its favorable characteristics as mechanical proprieties and biocompatibility, demonstrated by in vivo studies with animal models and clinical trials over a forty-year ...
Alfonso Pozio, Annalisa Palmieri, Ambra Girardi, Francesca Cura, Francesco Carinci   +4 more
doaj   +1 more source

25-Hydroxyvitamin D-3 induces osteogenic differentiation of human mesenchymal stem cells [PDF]

, 2016
25-Hydroxyvitamin D-3 [25(OH)D-3] has recently been found to be an active hormone. Its biological actions are demonstrated in various cell types. 25(OH)D-3 deficiency results in failure in bone formation and skeletal deformation.
Lou, Yan-Ru, Tee, Yee Han, Toh, Tai Chong, Yu, Hanry   +3 more
core   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies [PDF]

, 2017
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of ...
A Eddleston, AL Boskey, AR Shakoori, C Lipps, C Rentsch, Carolina Sañudo, CI Westacott, CM Cowan, D Benayahu, D Vanderschueren, Flor M. Pérez-Campo, G Jones, H Ishida, H Sudo, H Tullberg-Reinert, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, Jana Arozamena, Jeannette Zauers, Jesús Delgado-Calle, JN Beresford, José A. Riancho, JP Leeuwen van, LG Rao, María T. Berciano, MH Mankani, MH Mankani, Miguel Lafarga, MK Sutherland, MM Wong, MP Whyte, N Maruotti, NK Lee, PV Bodine, SA Harris, SA Stewart, SB Rodan, SH Scharla, T Matsumoto, TJ Shaw, TL Chen, Tobias May, U Valentiner, X Li, Y Suzuki   +46 more
core   +2 more sources

A heterozygous mutation in the ALPL gene in an adolescent with Chiari malformation type I accompanied by scoliosis, tethered cord and diastematomyelia [PDF]

, 2023
Liqing Xu, Chao Ma, Shengli Shen, Hongzhou Duan, Xiaoyan Li   +4 more
openalex   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Overexpression of hsa-miR-125b during osteoblastic differentiation does not influence levels of Runx2, osteopontin, and ALPL gene expression

Brazilian Journal of Medical and Biological Research, 2013
Multipotent mesenchymal stromal cells (MSCs) were first isolated from bone marrow and then from various adult tissues including placenta, cord blood, deciduous teeth, and amniotic fluid.
M.T. Pinto, L.D.F. Nicolete, E.S. Rodrigues, P.V.B. Palma, M.D. Orellana, S. Kashima, D.T. Covas   +6 more
doaj   +1 more source

Primary osteoblast-like cells from patients with end-stage kidney disease reflect gene expression, proliferation, and mineralization characteristics ex vivo. [PDF]

, 2015
Osteocytes regulate bone turnover and mineralization in chronic kidney disease. As osteocytes are derived from osteoblasts, alterations in osteoblast function may regulate osteoblast maturation, osteocytic transition, bone turnover, and skeletal ...
Bowen, Richard E, Delany, Anne M, Freymiller, Earl G, Khouzam, Nadine M, Pereira, Renata C, Salusky, Isidro B, Wesseling-Perry, Katherine   +6 more
core   +2 more sources

In Vitro Evaluation of Novel Calcium Silicate‐Based and Resin‐Modified Calcium Silicate Materials: Cytocompatibility and Mineralization Potential on Human Dental Pulp Stem Cells for Pulp Repair

Microscopy Research and Technique, EarlyView.
This study demonstrates that Biodentine XP exhibits superior cytocompatibility, promotes odontogenic differentiation, and enhances mineralization in human dental pulp stem cells, supporting its use in regenerative endodontics. Resin‐modified materials showed lower bioactivity, highlighting the importance of material composition in pulp therapy outcomes.
Francisco Javier Rodríguez‐Lozano, Nuria Pérez‐Guzmán, Paula García‐Rios, David García‐Bernal, Adrián Lozano, Sergio López‐García   +5 more
wiley   +1 more source