Results 71 to 80 of about 13,848 (209)
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene
Frontiers in Endocrinology, 2023 IntroductionHypophosphatasia (HPP) is an inborn metabolic error caused by mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSALP) and leading to decreased alkaline phosphatase (ALP) activity. Although the main characteristic of this disease is bone involvement, it presents a great genetic and clinical variability, which ...
Luis Martínez-Heredia +25 more
openaire +3 more sources
Titanium nanotubes activate genes related to bone formation in vitro
Dental Research Journal, 2012 Background: Titanium is used worldwide to make osseointegrable devices, thanks to its favorable characteristics as mechanical proprieties and biocompatibility, demonstrated by in vivo studies with animal models and clinical trials over a forty-year ...
Alfonso Pozio +4 more
doaj +1 more source
An Improved Proof-Theoretic Compilation of Logic Programs
, 2012 In prior work, we showed that logic programming compilation can be given a proof-theoretic justification for generic abstract logic programming languages, and demonstrated this technique in the case of hereditary Harrop formulas and their linear variant.
Cervesato, Iliano
core +1 more source
Microscopy Research and Technique, EarlyView.This study demonstrates that Biodentine XP exhibits superior cytocompatibility, promotes odontogenic differentiation, and enhances mineralization in human dental pulp stem cells, supporting its use in regenerative endodontics. Resin‐modified materials showed lower bioactivity, highlighting the importance of material composition in pulp therapy outcomes.
Francisco Javier Rodríguez‐Lozano +5 more
wiley +1 more source
On uniform canonical bases in $L_p$ lattices and other metric structures
, 2012 We discuss the notion of \emph{uniform canonical bases}, both in an abstract manner and specifically for the theory of atomless $L_p$ lattices. We also discuss the connection between the definability of the set of uniform canonical bases and the ...
Yaacov, Itaï Ben
core +3 more sources
Journal of Periodontology, EarlyView.Abstract Background Alveolar bone loss challenges tooth retention and implant placement. Freeze‐dried bone allograft (FDBA) is widely used for alveolar ridge preservation but has limitations in resorption rate and healing time. In this proof‐of‐concept study, we tested whether pro‐mineralization enzyme, tissue‐nonspecific alkaline phosphatase (TNAP ...
Kedith Sawangsri +4 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2013 Multipotent mesenchymal stromal cells (MSCs) were first isolated from bone marrow and then from various adult tissues including placenta, cord blood, deciduous teeth, and amniotic fluid.
M.T. Pinto +6 more
doaj +1 more source
Relativistic models of magnetars: the twisted-torus magnetic field configuration [PDF]
, 2009 We find general relativistic solutions of equilibrium magnetic field configurations in magnetars, extending previous results of Colaiuda et al. (2008).
Aguilera +28 more
core +2 more sources
Egg yolk hydrolysate shows moderate impact on osteoporosis in ovariectomized rats
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND This study investigated the protective effect of egg yolk hydrolysate (FC) on osteoporosis in ovariectomized (OVX) rats, a well‐established model of postmenopausal bone loss. OVX rats were fed diets supplemented with 0.2% or 1% FC for 13 weeks.
Ilekuttige Priyan Shanura Fernando +4 more
wiley +1 more source