Results 71 to 80 of about 5,335 (170)

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Analysis of Correlated Image Features Using Scalar‐On‐Matrix Regression

Statistical Analysis and Data Mining: An ASA Data Science Journal, Volume 19, Issue 2, April 2026.
ABSTRACT Image features from digital kidney biopsies may serve as novel biomarkers of kidney function in glomerular disease. Every subject's biopsy contains a different number of histologic objects, and for every object, a common set of image features is measured across all subjects.
Jeremy Rubin, Fan Fan, Laura Barisoni, Andrew R. Janowczyk, Jarcy Zee   +4 more
wiley   +1 more source

The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children

BMC Pediatrics
Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome.
Moushira Zaki, Hisham A. Orban, Mohamed A. Shahba, Rehab S. I. Moustafa, Ahmed Adel, Fatina I. Fadel, Abeer Selim, Hala T. El-Bassyouni, Eman R. Youness   +8 more
doaj   +1 more source

Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report

Annals of Internal Medicine: Clinical Cases
Complete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB.
Zuoyi Zhou, Long Zhang, Qinhui Sheng, Yanjun Gong, Jianping Li   +4 more
doaj   +1 more source

Increased in vivo transduction of AAV-9 cargo in Alport podocytes [version 1; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research
Background Alport syndrome is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and eye abnormalities. It is caused by variants in the COL4A3, COL4A4 or COL4A5 genes, which disrupt the synthesis, secretion and assembly of
Emily Williams, Kevin A. Goncalves, Shota Kaseda, Antony Adamson, Maryline Fresquet, Andrew Steinsapir, David R. Sherwood, Rachel Lennon, Gema Bolas   +8 more
doaj   +1 more source

A Case With Renal Failure, Hearing Loss and Double Ureters

Turkish Journal of Nephrology, 2019
In nephrology practice, the association of renal failure and deafness immediately brings to mind the Alport syndrome. However, in the differential diagnosis of deafness and renal failure a great number of syndromes ranging from Alport to Muckle-Wells ...
Kübra KAYNAR, Gülsüm ÖZKAN, Semih GÜL, Murat KAPUSUZ, Ümit ÇOBANOĞLU, Polat KOŞUCU, Şükrü ULUSOY   +6 more
doaj  

Pathogenic variants in the Alport genes are prevalent in the Singapore multiethnic population with highest frequency in the Chinese

Scientific Reports
Alport syndrome is a common monogenic kidney disease resulting from pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The estimated global population prevalence is one in 106 individuals for autosomal dominant (AD) and one in 2,320 for sex-linked ...
Tina Si Ting Lim, Chee Teck Koh, Judith Savige, Alvin Yu-Jin Ng, Jun Li Ng, Hui-Lin Chin, Weng Khong Lim, Gek Cher Chan, See Cheng Yeo, Esther Hui Min Leow, Benedict Junrong Yan, Kar Hui Ng, Yaochun Zhang   +12 more
doaj   +1 more source

Stair-Case/Honeycomb Maculopathy in Alport Syndrome: A Case Report

Case Reports in Ophthalmology
Introduction: Alport syndrome is an inherited disease caused by mutations in COL4A5, COLA3, or COL4A4 resulting in kidney failure, hearing loss, and ocular symptoms.
Zainab Rustam, Sarah Aman, Nakul Singh, Rose Tan, Amir H. Kashani, Peter A. Campochiaro   +5 more
doaj   +1 more source

Alport's syndrome.

Ear, nose, & throat journal, 1990
We review Alport's syndrome based on the description of seven members of a family whose disease was confirmed by percutaneous biopsy of renal specimens. The importance of genetic counseling and of the prophylaxis of hearing losses through cochlear protection is emphasized.
D, Catandi M di, J A, de Oliveira, R S, Costa   +2 more
openaire   +1 more source

Alport syndrome

Kidney International, 1996
Kashtan, Clifford E., Michael, Alfred F.
openaire   +2 more sources