Results 71 to 80 of about 6,046 (238)

High‐Throughput Heterospheroid‐Based Screening Identifies Drugs That Reprogram Tumor‐Associated Macrophages

open access: yesJournal of Immunology Research, Volume 2026, Issue 1, 2026.
The tumor microenvironment (TME) provides a niche for immune evasion and immunotherapy resistance, in part, by recruiting pro‐tumor M2‐like macrophages. In the present study, using heterospheroids consisting of cancer cells and macrophages, we identified TAM activators, which are compounds that reprogram M2‐like tumor‐associated macrophages (TAMs ...
Hiroyuki Tsuchiya   +7 more
wiley   +1 more source

Treatments for dry age-related macular degeneration and Stargardt disease : a systematic review [PDF]

open access: yes, 2018
Background Age-related macular degeneration (AMD) is the leading cause of visual loss in older people. Advanced AMD takes two forms, neovascular (wet) and atrophic (dry). Stargardt disease (STGD) is the commonest form of inherited macular dystrophy.
Colquitt, Jill   +6 more
core   +3 more sources

Relationship Between COVID‐19 and Retinal Artery Occlusions

open access: yesJournal of Ophthalmology, Volume 2026, Issue 1, 2026.
The relationship between coronavirus disease 2019 (COVID‐19) infection or vaccination and retinal artery occlusions (RAOs) remains controversial. COVID‐19 infection or vaccination can sometimes cause thrombin formation. RAOs occur due to thrombin in the retinal artery.
Tetsuya Muto   +4 more
wiley   +1 more source

Surprises of off-label drug use - where had all the Prostin gone? [PDF]

open access: yes, 2016
The off-label use of drugs is common, particularly in paediatrics, where many drugs have yet to undergo the rigorous scrutiny demanded by authorities such as the Medicines Control Council (MCC) and the US Food and Drug Administration (FDA) before ...
De Decker, Rik   +3 more
core  

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

open access: yes, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N   +8 more
core   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

open access: yesAdvanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu   +9 more
wiley   +1 more source

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

open access: yes, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam   +18 more
core   +2 more sources

In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug [PDF]

open access: gold, 2020
Ksenia M. Shestakova   +9 more
openalex   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 39, Issue 10, Page 1725-1737, October 2025.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Current pharmacological agents for the treatment of premature ejaculation [PDF]

open access: yes, 2014
This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious impact on the quality of life for
Okan Baş, Onur Dede, Şahin Bağbancı
core   +1 more source

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