Results 91 to 100 of about 2,287,133 (314)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis

Cell Reports
Summary: Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
Chong Gao, Qinghua Shi, Xue Pan, Jiajia Chen, Yuhong Zhang, Jiali Lang, Shan Wen, Xiaodong Liu, Tian-Lin Cheng, Kai Lei   +9 more
doaj   +1 more source

Nogo Provides a Molecular Marker for Diagnosis of Amyotrophic Lateral Sclerosis

Neurobiology of Disease, 2002
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the selective degeneration of upper and lower motor neurons. The lack of a molecular diagnostic marker is of increasing concern in view of the therapeutic strategies in
Luc Dupuis, Jose-Luis Gonzalez de Aguilar, Franck di Scala, Frédérique Rene, Marc de Tapia, Pierre-François Pradat, Lucette Lacomblez, Danielle Seihlan, Rabinder Prinjha, Frank S. Walsh, Vincent Meininger, Jean-Philippe Loeffler   +11 more
doaj   +1 more source

Evaluating the effect of a new inhibitor of USP14 in a Drosophila model of ALS [PDF]

openProtein and organelle homeostasis (proteostasis) comprises the cellular mechanisms responsible for maintaining protein and organelle stability, which is essential for cell physiology and proper function.
LUCIANO, SONIA
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Design and engineering of human TRAIL variants [PDF]

, 2006
TRAIL is een humaan eiwit dat bepaalde typen kankercellen aanzet tot geprogrammeerde celdood (apoptose) terwijl het normale cellen met rust laat. Hierdoor is TRAIL een veel­belovend potentieel anti kanker geneesmiddel.
Sloot, Albert Martinus, Sloot, Albert Martinus,   +1 more
core   +14 more sources

Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol [PDF]

, 1991
Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus.
Batten, J J, Calam, J, Freeman, T C, Vesey, D A, Batten, JJ, Baron, J H, Baron, JH, Playford, RJ, Fenn, GC, Freeman, TC, Beardshall, K, Playford, R J, Beardsall, K, Fenn, G C, Vesey, DA   +14 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Resistencia de Fimbristylis littoralis Gaudich a imazapir+imazetapir y su control con otros herbicidas en el cultivo de arroz

Bioagro
Fimbristylis littoralis Gaudich es una maleza que ha evolucionado resistencia a pirazosulfurón-etilo (inhibidor de la enzima acetolactato sintasa, ALS) en siembras de arroz en el estado Guárico, Venezuela.
Aída Ortiz, Pedro Pérez, Alvaro Anzalone, Castor Zambrano, Sandra Torres, Yinerby Quintana, Aída López, Luis López, Albert Fischer   +8 more
doaj  

Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease

Cell Death and Disease
Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we identify
Meng-Lu Liu, Shuaipeng Ma, Wenjiao Tai, Xiaoling Zhong, Haoqi Ni, Yuhua Zou, Jingcheng Wang, Chun-Li Zhang   +7 more
doaj   +1 more source

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

, 2019
OBJECTIVE: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS).
Airlie House ALS Clinical Trials Guidelines Group
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