Results 51 to 60 of about 2,857 (146)

Epidemiology of acquired hypothalamic obesity following traumatic brain injury and nonspecific hypothalamic microinjury: A nationwide German claims data analysis

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Acquired hypothalamic obesity (aHO) is characterized by rapid and persistent weight gain resulting from structural or functional damage to the hypothalamus, typically accompanied by neuroendocrine dysfunction. While aHO is well described in the context of hypothalamic or suprasellar tumors, particularly craniopharyngioma, little is known about
Julian Witte, Nicolas Touchot, Manuel Batram, Jana Diekmannshemke, Mathias Flume, Hermann L. Müller   +5 more
wiley   +1 more source

A Rare Syndromic Report of a Young Patient with Type 2 Diabetes Mellitus: Alstrom Syndrome

Case Reports in Clinical Practice
Alström syndrome is a rare multi-system congenital disorder with varied phenotypic presentations, including obesity, early-onset blindness, hearing loss, and various cardiac and renal manifestations.
Apoorva Suran, Jaideep Khare
doaj   +1 more source

Alstrom syndrome: A rare genetic disorder and its anaesthetic significance

Indian Journal of Anaesthesia, 2010
Alstrom syndrome is a rare autosomal recessive disorder that was first described in 1959, by Carl Henry Alstrom, characterised by multiorgan system involvement ranging from ocular, aural, endocrinal, hepatorenal, gastrointestinal, respiratory and cardiac
Akhilesh Tiwari, Disha Awasthi, Swapnil Tayal, S Ganguly   +3 more
doaj   +1 more source

Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

Frontiers in Endocrinology, 2022
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos, Elena Casanueva-Álvarez, Carlos M. González-Casimiro, Beatriz Merino, Germán Perdomo, Irene Cózar-Castellano, Irene Cózar-Castellano, Irene Cózar-Castellano   +7 more
doaj   +1 more source

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Association Between Physical Activity and Indicators of Overweight/Obesity and Metabolically Unhealthy Obesity Risk in Children and Adolescents: A Systematic Review of Prospective Epidemiological Studies and Randomized Controlled Trials in Western Countries

Obesity Reviews, Volume 27, Issue 1, Page 1-28, January 2026.
ABSTRACT This systematic review examined the etiologic association between physical activity (PA) and indicators of childhood overweight/obesity (OV/OB) and metabolically unhealthy obesity (MUO) risk. Original peer‐reviewed English reports published between January 01, 2013, and June 30, 2024, were retrieved from MEDLINE and Scopus.
Michael Georgoulis, Ismini Grapsa, Giannis Arnaoutis, Vasiliki Bountziouka, Alexandra Karachaliou, Georgios Saltaouras, Eirini Bathrellou, Mary Yannakoulia, George Dimitrakopoulos, Meropi D. Kontogianni   +9 more
wiley   +1 more source

Brain involvement in Alström syndrome

Orphanet Journal of Rare Diseases, 2013
Background Alström Syndrome (AS) is a rare ciliopathy characterized by cone–rod retinal dystrophy, sensorineural hearing loss, obesity, type 2 diabetes mellitus and cardiomyopathy.
Citton Valentina, Favaro Angela, Bettini Vera, Gabrieli Joseph, Milan Gabriella, Greggio Nella Augusta, Marshall Jan D, Naggert Jürgen K, Manara Renzo, Maffei Pietro   +9 more
doaj   +1 more source

The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway. [PDF]

PLoS ONE, 2012
Alström syndrome (ALMS) is a progressive multi-systemic disorder characterized by cone-rod dystrophy, sensorineural hearing loss, childhood obesity, insulin resistance and cardiac, renal, and hepatic dysfunction. The gene responsible for Alström syndrome,
Gayle B Collin, Jan D Marshall, Benjamin L King, Gabriella Milan, Pietro Maffei, Daniel J Jagger, Jürgen K Naggert   +6 more
doaj   +1 more source

Protection From Clinical Peripheral Sensory Neuropathy in Alström Syndrome in Contrast to Early-Onset Type 2 Diabetes [PDF]

, 2008
OBJECTIVE—Alström syndrome, with type 2 diabetes, and blindness could confer a high risk of foot ulceration. Clinical testing for neuropathy in Alström syndrome and matched young-onset type 2 diabetic subjects was therefore ...
Barnett, Sue, Bower, Lynne, Maffei, Pietro, Marshall, Jan D., Paisey, Richard B., Paisey, Rosamund M., Shield, Julian P.H., Thomson, Mary P.   +7 more
core   +2 more sources

Hyperglycemic Hyperosmolar State as the Initial Presentation of Wolfram Syndrome: A Common Complication Revealing a Rare Disease—A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
MRI brain revealing features consistent with central diabetes insipidus (Figure A), pontine atrophy (Figure B), and bilateral optic nerve atrophy (Figure C) in a young, non‐autoimmune diabetic patient: imaging clue to Wolfram syndrome. ABSTRACT Wolfram syndrome is a rare autosomal recessive disorder characterized by diabetes insipidus, diabetes ...
Sushrut Ingawale, Ishaan Shinde, Sai Teja Rachakonda, Ashmita Pandey, Ayushi Shah   +4 more
wiley   +1 more source