Results 71 to 80 of about 2,862 (212)

Association Between Physical Activity and Indicators of Overweight/Obesity and Metabolically Unhealthy Obesity Risk in Children and Adolescents: A Systematic Review of Prospective Epidemiological Studies and Randomized Controlled Trials in Western Countries

Obesity Reviews, Volume 27, Issue 1, Page 1-28, January 2026.
ABSTRACT This systematic review examined the etiologic association between physical activity (PA) and indicators of childhood overweight/obesity (OV/OB) and metabolically unhealthy obesity (MUO) risk. Original peer‐reviewed English reports published between January 01, 2013, and June 30, 2024, were retrieved from MEDLINE and Scopus.
Michael Georgoulis, Ismini Grapsa, Giannis Arnaoutis, Vasiliki Bountziouka, Alexandra Karachaliou, Georgios Saltaouras, Eirini Bathrellou, Mary Yannakoulia, George Dimitrakopoulos, Meropi D. Kontogianni   +9 more
wiley   +1 more source

A systematic review of mortality in schizophrenia - Is the differential mortality gap worsening over time? [PDF]

, 2007
Context Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
Chant, David C., McGrath, John J., Saha, S.   +2 more
core   +1 more source

Hyperglycemic Hyperosmolar State as the Initial Presentation of Wolfram Syndrome: A Common Complication Revealing a Rare Disease—A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
MRI brain revealing features consistent with central diabetes insipidus (Figure A), pontine atrophy (Figure B), and bilateral optic nerve atrophy (Figure C) in a young, non‐autoimmune diabetic patient: imaging clue to Wolfram syndrome. ABSTRACT Wolfram syndrome is a rare autosomal recessive disorder characterized by diabetes insipidus, diabetes ...
Sushrut Ingawale, Ishaan Shinde, Sai Teja Rachakonda, Ashmita Pandey, Ayushi Shah   +4 more
wiley   +1 more source

Brain involvement in Alström syndrome

Orphanet Journal of Rare Diseases, 2013
Background Alström Syndrome (AS) is a rare ciliopathy characterized by cone–rod retinal dystrophy, sensorineural hearing loss, obesity, type 2 diabetes mellitus and cardiomyopathy.
Citton Valentina, Favaro Angela, Bettini Vera, Gabrieli Joseph, Milan Gabriella, Greggio Nella Augusta, Marshall Jan D, Naggert Jürgen K, Manara Renzo, Maffei Pietro   +9 more
doaj   +1 more source

Consensus clinical management guidelines for Alström syndrome

Orphanet Journal of Rare Diseases, 2020
Alström Syndrome (ALMS) is an ultra-rare multisystem genetic disorder caused by autosomal recessive variants in the ALMS1 gene, which is located on chromosome 2p13.
Natascia Tahani, Pietro Maffei, Hélène Dollfus, Richard Paisey, Diana Valverde, Gabriella Milan, Joan C. Han, Francesca Favaretto, Shyam C. Madathil, Charlotte Dawson, Matthew J. Armstrong, Adrian T. Warfield, Selma Düzenli, Clair A. Francomano, Meral Gunay-Aygun, Francesca Dassie, Vincent Marion, Marina Valenti, Kerry Leeson-Beevers, Ann Chivers, Richard Steeds, Timothy Barrett, Tarekegn Geberhiwot   +22 more
doaj   +1 more source

BCAP is a centriolar satellite protein and inhibitor of ciliogenesis [PDF]

, 2017
The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis, and tissue homeostasis. The two organelles are mutually exclusive.
Ansley, Badano, Balczon, Basto, Bornens, Collin, Dawe, Doxsey, Ferrante, Fry, Hoh, Huangfu, Kasahara, Kim, Kubo, Lange, Luxton, Mikule, Mogensen, Nakagawa, Nigg, Nobes, Novorol, Ong, Pampliega, Ponsard, Sambrook, Satir, Schmidt, Singla, Sorokin, Stevens, Stowe, Tang, Tassin, Tollenaere, Tsang, Uetake, Wells   +38 more
core   +1 more source

Six Years of Genetic Diagnosis of Severe Early‐Onset Obesity in a French Cohort

Obesity Science &Practice, Volume 11, Issue 6, December 2025.
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
M. Rama, E. Blond, A. Janin, M. Di‐Filippo, C. Cuerq, O. Marmontel, P. A. Rollat‐Farnier, E. Dieterlen, B. Segrestin, M. Nicolino, E. Disse, K. Perge, D. Collin‐Chavagnac   +12 more
wiley   +1 more source

Early diagnosis of Bardet-Biedl syndrome associated with obesity

Ожирение и метаболизм, 2008
One of the urgent problems of modern health care is the increase in the prevalence of obesity among children and adolescents. Late diagnosis and delayed initiation of treatment lead to serious complications such as hypertension, type 2 diabetes mellitus.

doaj   +1 more source

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet? [PDF]

, 2019
Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors.
Barrea, L., Colao, A., Di Somma, C., Laudisio, D., Muscogiuri, G., Pugliese, G., Salzano, C., Savastano, S.   +7 more
core   +1 more source

Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches

Brain and Behavior, Volume 15, Issue 11, November 2025.
To systematically identify risk medications for migraine and its subtypes, we integrated GWAS data for 23 medications with GWASs of migraine and its subtypes to conduct causal inference. We then combined plasma eQTLs with drug‐target databases to map putative targets of the risk medications and validated causal relationships using colocalization and ...
Nan Wang, Weixuan Liang, Zhuofeng Wen, Wanzhe Liao, Zhixin Xie, Zhiyi Zhou, Ziyang Yang, Xitong Ju, Haobin Zhou, Chuiguo Huang   +9 more
wiley   +1 more source