Results 151 to 160 of about 351,811 (290)

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells. [PDF]

Nat Commun
Wu Y, Cai Z, Cross D, Noble JR, Prest K, Littleboy J, Cohen SB, Edlundh B, Koh JMS, Xu R, Noor Z, Bastami M, Valentini S, Richardson L, Barthorpe S, Arymanesh N, Robinson PJ, Hains PG, Garnett MJ, Zhong Q, Reddel RR, MacKenzie KL.   +21 more
europepmc   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Higher risk of postpartum phase transition to immune-active among HBeAg-positive pregnant women with indeterminate phase. [PDF]

Front Cell Infect Microbiol
Tang Q, Wang CR, Li H, Chen ZW, Liu XQ, Xue YL, Qiu Y, Cai N, Zeng Y, Hu P.   +9 more
europepmc   +1 more source

Sonlu Elemanlar Yöntemleri İle Yapısal Dinamik Analiz Cevaplarının Süper Elemanlar Ve Alt Yapılara Bölme İle İyileştirilmesi

, 2009
Fikret Kamil Çorbacı
openalex   +1 more source

Classroom Strategies and Challenges: A Case Study of a Filipino Assistant Language Teacher (ALT) in Japan [PDF]

Mike Lawrence G. Ratunil, Jeffrey M. Tinagan, Doreen E. Cabunilas, Dominic Bryan S. San Jose   +3 more
openalex   +1 more source

Erratum-title alt-title-type="runhead" /> [PDF]

, 2019
Resnikoff, S, Jonas, JB, Friedman, D, He, M, Jong, M, Nichols, JJ, Ohno-Matsui, K, Smith, EL, Wildsoet, CF, Taylor, HR, Wolffsohn, JS, Wong, TY   +11 more
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Sistemas diagnósticos de exacerbación de la EPOC en la población anciana: presente y futuro

Open Respiratory Archives
César Gálvez-Barrón, Carlos Pérez-López   +1 more
doaj   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source