Results 201 to 210 of about 58,127 (309)

No direction home? Futures for post-colonial studies [PDF]

, 1996
Williams, P
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

'Why Bother?' Skeptical Doubt and Moral Imagination in Care for People with Profound Intellectual Disabilities. [PDF]

Cult Med Psychiatry
van der Weele S.
europepmc   +1 more source

Béatrice Longuenesse: Hegel’s Critique of Metaphysics [PDF]

, 2012
Yeomans, Christopher
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Close, yet so far away: a phenomenology of the praecox feeling in the diagnosis of schizophrenia as intercorporeal alienness. [PDF]

Front Psychiatry
Vial I, Moskalewicz M, Szuła A, Schwartz MA, Fuchs T.   +4 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease. [PDF]

Pharmacotherapy
Longardner K, Liu C, Momper J, Mahato K, Moonla C, Ghodsi H, Wang J, Litvan I.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Effect of Diagnostic Hypercapnic Cerebrovascular Reactivity Imaging on Vital Signs and Acute and Follow-Up Ischemic Adverse Events in Patients with Flow-Limiting Intracranial Arterial Stenosis. [PDF]

AJNR Am J Neuroradiol
Leguizamon M, Han C, Garza M, Horne M, Richerson WT, Davis LT, Martin D, Fusco M, Chitale R, Jordan LC, Donahue MJ.   +10 more
europepmc   +1 more source