Results 101 to 110 of about 350,171 (307)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Evaluation of the Physiological Host Range for the Parasitoid Ooencyrtus mirus, a Potential Biocontrol Agent of Bagrada hilaris

Insects, 2020
The thelytokous egg parasitoid Ooencyrtus mirus Triapitsyn and Power (Hymenoptera: Encyrtidae) was recovered from brassica plant debris in Pakistan in an effort to find a biological control agent of the invasive bug Bagrada hilaris (Burmeister ...
Nancy Power, Fatemeh Ganjisaffar, Thomas M. Perring   +2 more
doaj   +1 more source

The role of water and steric constraints in the kinetics of cavity-ligand unbinding

, 2015
A key factor influencing a drug's efficacy is its residence time in the binding pocket of the host protein. Using atomistic computer simulation to predict this residence time and the associated dissociation process is a desirable but extremely difficult ...
Berne, B. J., Mondal, Jagannath, Morrone, Joseph A., Tiwary, Pratyush   +3 more
core   +1 more source

Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution [PDF]

, 2018
Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P.
Arnathau, Céline, Boundenga, Larson, Durand, Patrick, Franzon, Blaise, Gilabert, Aude, Makanga, Boris, Moukodoum, Nancy D., Ngoubangoye, Barthélémy, Okouga, Alain-Prince, Ollomo, Benjamin, Otto, Thomas D., Paupy, Christophe, Prugnolle, Franck, Renaud, François, Rougeron, Virginie, Rutledge, Gavin G.   +15 more
core   +5 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Aphid gene expression following polerovirus acquisition is host species dependent

Frontiers in Plant Science
Upon acquisition of persistent circulative viruses such as poleroviruses, the virus particles transcytose through membrane barriers of aphids at the midgut and salivary glands via hemolymph.
Sudeep Pandey, Michael Catto, Phillip Roberts, Sudeep Bag, Alana L. Jacobson, Rajagopalbabu Srinivasan   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Barberry plays an active role as an alternate host of Puccinia graminis in Spain. [PDF]

Plant Pathol, 2022
Villegas D, Bartaula R, Cantero-Martínez C, Luster D, Szabo L, Olivera P, Berlin A, Rodriguez-Algaba J, Hovmøller MS, McIntosh R, Jin Y.   +10 more
europepmc   +1 more source

Magellan Spectroscopy of Low-Redshift Active Galactic Nuclei

, 2009
We present an atlas of moderate-resolution (R ~ 1200-1600) optical spectra of 94 low-redshift (z < 0.5) active galactic nuclei taken with the Magellan 6.5 m Clay Telescope. The spectra mostly cover the rest-frame region 3600-6000 Ang.
Baldwin, Bentz, Boller, Greene, Greene, Greene, Grupe, Hamilton, Ho, Ho, Ho, Hu, Hu, Kaspi, Kaspi, Kim, Kim, Kim, Kuraszkiewicz, Luis C. Ho, Marziani, Minjin Kim, Netzer, Schlegel, Spergel, Stone, Vestergaard   +26 more
core   +1 more source

Alternative host shapes transmission and life‐history trait correlations in a multi‐host plant pathogen

Evolutionary Applications, 2022
Abstract Most pathogens are generalists capable of infecting multiple host species or strains. Trade‐offs in performance among different hosts are expected to limit the evolution of generalism. Despite the commonness of generalism, the variation in infectivity, transmission, and trade‐offs in performance among ...
openaire   +4 more sources