Results 1 to 10 of about 248,910 (261)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

mBio, 2023
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König   +7 more
doaj   +1 more source

Senescence and Host–Pathogen Interactions [PDF]

Cells, 2020
Damage to our genomes triggers cellular senescence characterised by stable cell cycle arrest and a pro-inflammatory secretome that prevents the unrestricted growth of cells with pathological potential. In this way, senescence can be considered a powerful innate defence against cancer and viral infection.
Daniel Humphreys, Mohamed ElGhazaly, Teresa Frisan   +2 more
openaire   +6 more sources

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis

mBio, 2022
Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy.
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez   +7 more
doaj   +1 more source

Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection

Scientific Reports, 2021
While considered an extracellular pathogen, Pseudomonas aeruginosa has been reported to be engulfed by macrophages in cellular and animal models. However, the role of macrophages in P. aeruginosa clearance in vivo remains poorly studied.
Malika Moussouni, Laurence Berry, Tamara Sipka, Mai Nguyen-Chi, Anne-Béatrice Blanc-Potard   +4 more
doaj   +1 more source

Succession in the caecal microbiota of developing broilers colonised by extended-spectrum β-lactamase-producing Escherichia coli

Animal Microbiome, 2022
Background Broilers are among the most common and dense poultry production systems, where antimicrobials have been used extensively to promote animal health and performance.
Ingrid Cárdenas-Rey, Teresita d. J. Bello Gonzalez, Jeanet van der Goot, Daniela Ceccarelli, Gerwin Bouwhuis, Danielle Schillemans, Stephanie D. Jurburg, Kees T. Veldman, J. Arjan G. M. de Visser, Michael S. M. Brouwer   +9 more
doaj   +1 more source

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages

FEBS Open Bio, 2023
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis.
Beren Aylan, Laure Botella, Maximiliano G. Gutierrez, Pierre Santucci   +3 more
doaj   +1 more source

Phosphoinositides and host–pathogen interactions [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments.
Pizarro-Cerdá, Javier, Kühbacher, Andreas, Cossart, Pascale   +2 more
openaire   +3 more sources

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Nature Communications, 2021
Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination ...
Pierre Santucci, Daniel J. Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano G. Gutierrez   +5 more
doaj   +1 more source

Host-Pathogen Interactions of Retroviruses [PDF]

Molecular Biology International, 2012
Retroviruses, such as HIV-1, are enveloped RNA viruses that use the enzyme reverse transcriptase (RT) to make a DNA copy of their RNA genome during replication in the host cell. The retrovirus life cycle is generally divided into two distinct phases: the early and late phase.
Waheed, Abdul A., Brass, Abraham L., Gummuluru, Suryaram, Tachedjian, Gilda   +3 more
openaire   +2 more sources

Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice

Microbiology Spectrum, 2021
Inflammation plays a crucial role in the control of Mycobacterium tuberculosis infection. In this study, we demonstrate that an inflammatory pulmonary environment at the time of infection mediated by lipopolysaccharide treatment in mice confers enhanced ...
Tucker J. Piergallini, Julia M. Scordo, Paula A. Pino, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner   +5 more
doaj   +1 more source