Results 41 to 50 of about 4,341,821 (307)

Arrestins in Host–Pathogen Interactions

, 2013
In the context of host-pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism of defense, known as innate immunity, to block the aggression.
Marullo, Stefano, Coureuil, Mathieu
openaire   +4 more sources

Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment

Nature Communications
Slow growth rates are considered a hallmark of Mycobacterium tuberculosis (Mtb) and have been historically associated with persistence and subsequent drug tolerance.
Nathan J. Day, Baptiste Pradel, Chak Hon Luk, Pierre Santucci, Antony Fearns, Angela Rodgers, Beren Aylan, Laure Botella, Julien Vaubourgeix, Julio Ortiz Canseco, Natalia Athanasiadi, Maximiliano G. Gutierrez   +11 more
doaj   +1 more source

Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy

Frontiers in Immunology
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments.
Alla Bulashevska, Zsófia Nacsa, Franziska Lang, Markus Braun, Martin Machyna, Mustafa Diken, Liam Childs, Renate König   +7 more
doaj   +1 more source

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi–Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

Stem Cell Research, 2020
Aicardi-Goutières syndrome (AGS) is a hereditary early onset encephalopathy. AGS patients display variable clinical manifestations including intracranial calcification, cerebral atrophy, white matter abnormalities and characteristic leukocytosis as well ...
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Lena Wendeburg, Doris Steinemann, Christiane Elpers, Frank Rutsch, Renate König   +9 more
doaj   +1 more source

Microbial source tracking of fecal contamination in Laguna Lake, Philippines using the library-dependent method, rep-PCR

Journal of Water and Health, 2021
Laguna Lake is an economically important resource in the Philippines, with reports of declining water quality due to fecal pollution. Currently, monitoring methods rely on counting fecal indicator bacteria, which does not supply information on potential ...
Laurice Beatrice Raphaelle O. dela Peña, Kevin L. Labrador, Mae Ashley G. Nacario, Nicole R. Bolo, Windell L. Rivera   +4 more
doaj   +1 more source

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Host-pathogen interactions: can micronutrients tip the balance? [PDF]

, 2007
Nutrients are essential to the human host and to its invading pathogens. The purpose of this International Nutrition Council symposium on Micronutrient Regulation of Host-Pathogen Interactions held at Experimental Biology 2006 was to examine new ...
Cox, Sharon E, Ghattas, Hala, Prentice, Andrew M, Hala Ghattas, Sharon E. Cox, Andrew M. Prentice   +5 more
core   +1 more source

Host-Pathogen Interactions [PDF]

Plant Physiology, 1983
A bioassay to measure the incorporation of [(14)C]leucine into acid-precipitable polymers of suspension-cultured sycamore (Acer pseudoplatanus L.) cells is described. Using this assay, cell wall fragments solubilized from sycamore cell walls by partial acid hydrolysis are shown to contain components that inhibit the incorporation of [(14)C]leucine into
N, Yamazaki, S C, Fry, A G, Darvill, P, Albersheim   +3 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source