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Hologenomics: Systems-Level Host Biology [PDF]

mSystems, 2018
The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host ...
Kevin R. Theis
doaj   +3 more sources

Mycobacterium tuberculosis biology, pathogenicity and interaction with the host

Nature Reviews Microbiology
Since the release of the first Mycobacterium tuberculosis genome in 1998, major advances have been made in understanding the biology of this pathogen, the leading infectious cause of death in modern human history. In this Review, we outline the physiological and metabolic features thought to underpin the survival, evasion and subversion strategies ...
Digby F Warner, Amy K Barczak, Maximiliano G Gutierrez   +2 more
exaly   +3 more sources

Advanced Multiplex Loop Mediated Isothermal Amplification (mLAMP) Combined with Lateral Flow Detection (LFD) for Rapid Detection of Two Prevalent Malaria Species in India and Melting Curve Analysis

Diagnostics, 2021
Isothermal techniques with lateral flow detection have emerged as a point of care (POC) technique for malaria, a major parasitic disease in tropical countries such as India.
Supriya Sharma, Sandeep Kumar, Md Zohaib Ahmed, Nitin Bhardwaj, Jaskirat Singh, Sarita Kumari, Deepali Savargaonkar, Anupkumar R. Anvikar, Jyoti Das   +8 more
doaj   +1 more source

Nationwide spatiotemporal drug resistance genetic profiling from over three decades in Indian Plasmodium falciparum and Plasmodium vivax isolates

Malaria Journal, 2023
Background Drug resistance is a serious impediment to efficient control and elimination of malaria in endemic areas. Methods This study aimed at analysing the genetic profile of molecular drug resistance in Plasmodium falciparum and Plasmodium vivax ...
Loick P. Kojom Foko, Geetika Narang, Jahnvi Jakhan, Suman Tamang, Amit Moun, Vineeta Singh   +5 more
doaj   +1 more source

The spectrum of clinical biomarkers in severe malaria and new avenues for exploration

Virulence, 2022
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major share of the disease burden in malaria endemic countries. In this context, identification and validation of SM biomarkers are essential in clinical practice. Some
Loick Pradel Kojom Foko, Geetika Narang, Suman Tamang, Joseph Hawadak, Jahnvi Jakhan, Amit Sharma, Vineeta Singh   +6 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, 2023
AbstractNeutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
openaire   +2 more sources

Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool

Bioengineering, 2022
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy.
Amrendra Chaudhary, Poonam Kataria, Neha Surela, Jyoti Das   +3 more
doaj   +1 more source

CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogenesis

Malaria Journal, 2022
Background Regulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However, the role of naturally occurring regulatory cells CD4+CD25+Foxp3 + in malaria infection during the disease
Rubika Chauhan, Vikky Awasthi, Reva Sharan Thakur, Veena Pande, Debprasad Chattopadhyay, Jyoti Das   +5 more
doaj   +1 more source

AN ESTERASE-LIKE PROTEIN (ELP) CONFERRED MALATHION AND DELTAMETHRIN RESISTANCE IN THE INDIAN FIELD POPULATION OF ANOPHELES STEPHENSI

International Journal of Infectious Diseases, 2023
Intro: Chemical insecticides in the form of IRS (Indoor Residual Sprays) and LLITNs (Long Lasting Insecticide Treated Nets) comprise current malaria vector control strategies.
J. Kumar, K. Prasad, V. Kumari, K. Pandey   +3 more
doaj   +1 more source

Systems biology of host–microbe metabolomics [PDF]

WIREs Systems Biology and Medicine, 2015
The human gut microbiota performs essential functions for host and well‐being, but has also been linked to a variety of disease states, e.g., obesity and type 2 diabetes. The mammalian body fluid and tissue metabolomes are greatly influenced by the microbiota, with many health‐relevant metabolites being considered ‘mammalian–microbial co‐metabolites ...
HEINKEN, Almut Katrin, THIELE, Ines
openaire   +3 more sources