Results 61 to 70 of about 4,341,821 (307)

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

Nature Communications, 2018
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König   +14 more
doaj   +1 more source

Tuberculosis in an Aging World

Pathogens, 2022
Tuberculosis (TB) is one of the leading causes of death due to its being an infectious disease, caused by the airborne pathogen Mycobacterium tuberculosis (M.tb).
Angélica M. Olmo-Fontánez, Joanne Turner   +1 more
doaj   +1 more source

Evolutionary and proximate mechanisms shaping host-parasite interactions : the case of "Daphnia magna" and its natural bacterial parasite "Pasteuria ramosa" [PDF]

, 2011
Host-parasite interactions are composed of a sequence of steps, all necessary for successful infection: parasites need to encounter their hosts, to enter into their bodies, and to proliferate within them. Selection will act on the mechanisms used in each
Duneau, David
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Heterogeneous host susceptibility enhances prevalence of mixed-genotype micro-parasite infections [PDF]

, 2011
Dose response in micro-parasite infections is usually shallower than predicted by the independent action model, which assumes that each infectious unit has a probability of infection that is independent of the presence of other infectious units. Moreover,
Zwart, Mark P., Lia Hemerik, Hemerik, L., Just M. Vlak, Mark P. Zwart, Mark P Zwart, Vlak, J.M., van der Werf, Wopke, van der Werf Wopke, Hemerik, Lia, Just M Vlak, Hemerik Lia, Vlak Just M., Zwart Mark P., Zwart, M.P., Wopke van der Werf, Vlak, Just M., Werf, W., van der, van der Werf, W.   +18 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Limited impact of schistosome infection on Biomphalaria glabrata snail microbiomes

Parasites & Vectors
Background The microbiome of disease vectors can be a key determinant of their ability to transmit parasites. Conversely, parasite infection may modify vector microbiomes. We explore the interactions between the Biomphalaria glabrata snail microbiome and
Stephanie C. Nordmeyer, Timothy J. C. Anderson, Winka Le Clec’h, Frédéric D. Chevalier   +3 more
doaj   +1 more source

Within-Host Dynamics of Multi-Species Infections:Facilitation, Competition and Virulence [PDF]

, 2012
Host individuals are often infected with more than one parasite species (parasites defined broadly, to include viruses and bacteria). Yet, research in infection biology is dominated by studies on single-parasite infections.
Eswarappa, Sandeepa M., Sylvie Estrela, Sam P Brown, Sylvie Estrela (156401), Estrela, Sylvie, Sam P. Brown (30600), Brown, Sam P., Sandeepa M Eswarappa, Sandeepa M. Eswarappa (156396)   +8 more
core   +2 more sources

Host–Pathogen Interactions [PDF]

Clinical Therapeutics, 2019
Scott D. Kobayashi, Frank R. DeLeo
  +5 more sources