Results 71 to 80 of about 4,341,821 (307)

Host–Pathogen Interaction in Invasive Salmonellosis

PLoS Pathogens, 2012
Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but whose clinical features differ from other Gram-negative bacteremias.
de Jong, Hanna K., Parry, Chris M., van der Poll, Tom, Wiersinga, W. Joost   +3 more
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils

Frontiers in Immunology, 2020
Polymorphonuclear neutrophils (PMN) are critical for first line innate immune defence against Staphylococcus aureus. Mature circulating PMN maintain a short half-life ending in constitutive apoptotic cell death.
Michelle E. Mulcahy, Eóin C. O’Brien, Kate M. O’Keeffe, Emilio G. Vozza, Neal Leddy, Rachel M. McLoughlin   +5 more
doaj   +1 more source

Molecular surveillance of Cryptosporidium spp. for microbial source tracking of fecal contamination in Laguna Lake, Philippines

Journal of Water and Health, 2021
Water quality deterioration in source waters poses increased health, environmental, and economic risks. Here, we genotyped Cryptosporidium spp. obtained from water samples of Laguna Lake, Philippines, and its tributaries for the purpose of source ...
Laurice Beatrice Raphaelle O. dela Peña, Mark Raymond A. Vejano, Windell L. Rivera   +2 more
doaj   +1 more source

Revealing the molecular signatures of host-pathogen interactions. [PDF]

, 2011
Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co ...
Martin L Hibberd, Khor, C.-C., Hibberd, Martin L, Chiea-Chuen Khor, Hibberd, M.L., Khor, Chiea-Chuen   +5 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense [PDF]

, 2012
Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors) and host resistance genes such as the major ...
Anja C. Hörger, Rose, Laura E., Renier A. L. Van Der, Renier A. L. van der Hoorn (150148), Van Der Hoorn, RAL, van der Hoorn, RA, Hoerger, A., Rose, LE, Van der Hoorn, R., Muhammad Ilyas, Laura E Rose, Ilyas, M, Laura E. Rose (150153), Hörger, Anja C., Laura E. Rose, Hoerger, AC, Rose, L., Aurélien Tellier, Van Der Hoorn, Renier, Stephan, Wolfgang, Hörger, AC, Tellier, A, Tellier, A., Muhammad Ilyas (150134), Anja C Hörger, van der Hoorn, Renier A. L., Anja C. Hörger (150127), Tellier, Aurélien, Stephan, W., Wolfgang Stephan (14960), Aurélien Tellier (150142), Renier A L van der Hoorn, Wolfgang Stephan, Stephan, W, Ilyas, M., Ilyas, Muhammad, van der Hoorn Renier A. L., Rose Laura E., Tellier Aurélien, Stephan Wolfgang, Hörger, Anja C.;Ilyas, Muhammad;Stephan, Wolfgang;Tellier, Aurélien;van der Hoorn, Renier A. L.;Rose, Laura E., Ilyas Muhammad, Hörger Anja C.   +42 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Host-pathogen interactions in Campylobacter infections: the host perspective [PDF]

, 2008
Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide. This study was aimed at summarizing the current understanding of host mechanisms involved in the defense against Campylobacter by evaluating data available from three sources:
Dep Infectieziekten Immunologie, Advances in Veterinary Medicine, Krogfelt, K.A., Robert J. Owen, Pelt, W., van, Karen A. Krogfelt, Shaun A. Cawthraw, Krogfelt, K., Strategic Infection Biology, Janssen, R., Wagenaar, J.A., van Pelt, W., Riny Janssen, Wilfrid van Pelt, Cawthraw, S.A., Jaap A. Wagenaar, Owen, R.J., Cawthraw, S., Owen, R.   +18 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source