Results 81 to 90 of about 4,341,821 (307)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

The EMBO Journal
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitment at the individual organelle level are unknown ...
Di Chen, Antony Fearns, Christopher J Peddie, Maximiliano G Gutierrez   +3 more
doaj   +1 more source

Mtb-Timer: a fluorescent reporter to visualize Mycobacterium tuberculosis replication and antibiotic responses

mSystems
Despite the importance of monitoring Mycobacterium tuberculosis (Mtb) replication and antibiotic responses at the single-cell level, available tools to accurately monitor single Mtb replication are limited. Here, we report the development of Mtb-Timer, a
Víctor Campo-Pérez, Chak Hon Luk, Laure Botella, Julien Vaubourgeix, Maximiliano G. Gutierrez   +4 more
doaj   +1 more source

Characterising within-hospitalSARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Nature Communications, 2022
SARS-CoV-2 has resulted in multiple outbreaks in hospitals, but identifying transmission events is challenging. Here, the authors combine whole genome sequencing and epidemiological data from the first two waves of the pandemic at a UK hospital trust and
Benjamin B. Lindsey, Ch. Julián Villabona-Arenas, Finlay Campbell, Alexander J. Keeley, Matthew D. Parker, Dhruv R. Shah, Helena Parsons, Peijun Zhang, Nishchay Kakkar, Marta Gallis, Benjamin H. Foulkes, Paige Wolverson, Stavroula F. Louka, Stella Christou, Amy State, Katie Johnson, Mohammad Raza, Sharon Hsu, Thibaut Jombart, Anne Cori, Sheffield COVID-19 Genomics Group, The COVID-19 Genomics UK (COG-UK) consortium, CMMID COVID-19 working group, Cariad M. Evans, David G. Partridge, Katherine E. Atkins, Stéphane Hué, Thushan I. de Silva   +27 more
doaj   +1 more source

The Host-Pathogen Interaction [PDF]

Cell, 2001
n ...
Rescigno, Maria, Borrow, Persephone
openaire   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Hippo signaling pathway regulates Ebola virus transcription and egress

Nature Communications
Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical regulators of EBOV transcription and egress.
Jingjing Liang, Marija A. Djurkovic, Carson G. Leavitt, Olena Shtanko, Ronald N. Harty   +4 more
doaj   +1 more source

Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1 [PDF]

, 2010
Fungal and oomycete plant pathogens translocate effector proteins into host cells to establish infection. However, virulence targets and modes of action of their effectors are unknown.
Hein, I., Dixelius, Christina, Hein, I, Hein, Ingo, Bryan, G, Dixelius, C., Kamoun, S., Gilroy, EM, Bos, JIB, Sadanandom, A, Boevink, PC, Gilroy, Eleanor M., Armstrong, MR, Bos, J. I. B., Taylor, RM, Bos, Jorunn I. B., Zhendong, T., Sadanandom, A., Boevink, Petra C., Dixelius, C, Engelhardt, Stefan, Bryan, Glenn, Birch, PRJ, Armstrong, M. R., Engelhardt, S, Hein, Ingo; id_orcid, Harrower, Brian, Kamoun, Sophien, Whisson, Stephen C., Vetukuri, R. R., Birch, Paul R. J.; id_orcid, Bryan, G., Vetukuri, RR, Engelhardt, S., Whisson, S. C., Tian, ZD, Whisson, SC, Boevink, P. C., Bryan, Glenn J., Bos, Jorunn, Gilroy, E. M., Sadanandom, Ari, Birch, Paul R. J., Harrower, B., Harrower, B, Vetukuri, Ramesh R., Birch, P. R. J., Taylor, R. M., Armstrong, Miles R., Taylor, Rosalind M., Zhendong, Tian, Kamoun, S, Tian, Zhendong, Sveriges lantbruksuniversitet., Ramesh, Vetukuri,, Dixelius, Christina,   +55 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source