Results 1 to 10 of about 2,189,693 (359)

Role of Protein Glycosylation in Host-Pathogen Interaction

Cells, 2020
Host-pathogen interactions are fundamental to our understanding of infectious diseases. Protein glycosylation is one kind of common post-translational modification, forming glycoproteins and modulating numerous important biological processes.
Bo-Rong Lin, X. Qing, J. Liao, K. Zhuo
semanticscholar   +1 more source

The Keystone Pathogen Hypothesis

Nature Reviews Microbiology, 2012
Recent studies have highlighted the importance of the human microbiome in health and disease. However, for the most part the mechanisms by which the microbiome mediates disease, or protection from it, remain poorly understood.
G. Hajishengallis, R. Darveau, M. Curtis
semanticscholar   +1 more source

hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice

Stem Cell Research & Therapy, 2020
Background Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury.
Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang, Chuan Su   +12 more
doaj   +1 more source

An update on the human and animal enteric pathogen Clostridium perfringens

Emerging Microbes and Infections, 2018
Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century.
R. Kiu, L. Hall
semanticscholar   +1 more source

Staphylococcus epidermidis – the “accidental” pathogen

Nature Reviews Microbiology, 2009
Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host.
M. Otto
semanticscholar   +1 more source

Alterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles

International Journal of Microbiology
Dynamics of gut microbiota and their associations with the corresponding hematological injuries postradiation remain to be elucidated. Using single whole-body exposure to 60Co-γ ray radiation at the sublethal dose of 2.5 Gy, we developed a beagle model ...
Zongyu Huang, Likun Wang, Jianghui Tong, Yong Zhao, Hui Ling, Yazhou Zhou, Yafang Tan, Xiaohui Xiong, Yefeng Qiu, Yujing Bi, Zhiyuan Pan, Ruifu Yang   +11 more
doaj   +1 more source

Ancient pathogen genomics as an emerging tool for infectious disease research

Nature reviews genetics, 2019
Over the past decade, a genomics revolution, made possible through the development of high-throughput sequencing, has triggered considerable progress in the study of ancient DNA, enabling complete genomes of past organisms to be reconstructed.
M. Spyrou, K. Bos, A. Herbig, J. Krause
semanticscholar   +1 more source

Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

Science, 2018
Degradation triggers the alarm Inflammasomes are multiprotein complexes that orchestrate proinflammatory cytokine secretion and cell death. Proteases such as anthrax lethal factor can activate an inflammasome known as NLRP1B, but the mechanism for this ...
A. Sandstrom, P. S. Mitchell, Lisa Goers, E. Mu, C. Lesser, R. Vance   +5 more
semanticscholar   +1 more source

First report of VGSC mutations for resistance to synthetic pyrethroids in brown dog ticks (Rhipicephalus sanguineus sensu stricto) from Brazil

Parasites & Vectors
Background Brown dog ticks, Rhipicephalus sanguineus sensu lato (s.l.), have spread globally and are an important vector of multiple pathogens affecting both dogs and humans.
Hayden Kleinschmidt, Nathan E. Stone, Rebecca Ballard, Natalie B. Thornton, Grant L. Pemberton, Simone Becker, Guilherme M. Klafke, David M. Wagner, Joseph D. Busch   +8 more
doaj   +1 more source

Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway

Scientific Reports, 2017
Schistosomiasis is characterized by egg deposition, granulomatous inflammatory reaction and then subsequent hepatic fibrosis formation. Activated HSCs are regarded as the main effector cells in the progression of liver fibrosis and induction of ...
Tianhua Xu, Jinling Chen, Dandan Zhu, Liuting Chen, Jianxin Wang, Xiaolei Sun, Bin Hu, Yinong Duan   +7 more
doaj   +1 more source