Results 31 to 40 of about 2,673,378 (401)

Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro

mBio, 2021
New therapeutics are urgently needed in the fight against COVID-19. Repurposing drugs that are either already approved for human use or are in advanced stages of the approval process can facilitate more rapid advances toward this goal.
Nathan E. Stone, Sierra A. Jaramillo, Ashley N. Jones, Adam J. Vazquez, Madison Martz, Lora M. Versluis, Marlee O. Raniere, Haley E. Nunnally, Katherine E. Zarn, Roxanne Nottingham, Ken R. Ng, Jason W. Sahl, David M. Wagner, Steen Knudsen, Erik W. Settles, Paul Keim, Christopher T. French   +16 more
doaj   +1 more source

An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2015
Background Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation ...
Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su   +13 more
doaj   +1 more source

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

Science, 2020
Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (
Raoul Martin, Tiancong Qi, Haibo Zhang, Furong Liu, Miles King, C. Toth, E. Nogales, B. Staskawicz   +7 more
semanticscholar   +1 more source

ASGDB: a specialised genomic resource for interpreting Anopheles sinensis insecticide resistance

Parasites & Vectors, 2018
Background Anopheles sinensis is an important malaria vector in Southeast Asia. The widespread emergence of insecticide resistance in this mosquito species poses a serious threat to the efficacy of malaria control measures, particularly in China ...
Dan Zhou, Yang Xu, Cheng Zhang, Meng-Xue Hu, Yun Huang, Yan Sun, Lei Ma, Bo Shen, Chang-Liang Zhu   +8 more
doaj   +1 more source

Oceanic Hitchhikers - Assessing Pathogen Risks from Marine Microplastic.

Trends in Microbiology, 2020
As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport.
J. Bowley, C. Baker‐Austin, A. Porter, R. Hartnell, C. Lewis   +4 more
semanticscholar   +1 more source

Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects

Frontiers in Microbiology, 2021
Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm.
Hao Li, Xuedong Zhou, Yuyao Huang, Binyou Liao, Lei Cheng, B. Ren   +5 more
semanticscholar   +1 more source

Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2017
Background The involvement of CD8+T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. Results In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 −/− mice ...
Lin Chen, Donghui Zhang, Wenyue Zhang, Yuxiao Zhu, Min Hou, Bingya Yang, Zhipeng Xu, Minjun Ji, Guanling Wu   +8 more
doaj   +1 more source

Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice

Parasites & Vectors, 2017
Background Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S.
Xiaofeng Luo, Yuxiao Zhu, Ran Liu, Jingwei Song, Fan Zhang, Wenyue Zhang, Zhipeng Xu, Min Hou, Bingya Yang, Lin Chen, Minjun Ji   +10 more
doaj   +1 more source

Viral pathogens [PDF]

Haemophilia, 2010
Summary.  Despite continuous improvement in safety and purity of blood products for individuals with haemophilia, transmissible agents continue to affect individuals with haemophilia. This chapter addresses three viral pathogens with significant clinical impact: HIV, hepatitis C and parvovirus B19.
M V, Ragni, K E, Sherman, J A, Jordan
openaire   +2 more sources

Evidence for the plant recruitment of beneficial microbes to suppress soil-borne pathogen

bioRxiv, 2020
Emerging experimental framework suggests that plants under biotic stress may actively seek help from soil microbes, but empirical evidence underlying such a ‘cry for help’ strategy is limited.
Hongwei Liu, Jiayu Li, Lilia C. Cavalhais, Cassandra D. Percy, J. Verma, P. Schenk, B. Singh   +6 more
semanticscholar   +1 more source