Results 51 to 60 of about 646,532 (282)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The round functions of KASUMI generate the alternating group

Journal of Mathematical Cryptology, 2015
We show that the round functions of the KASUMI block cipher for odd and even round type generate the alternating group on the message space. Moreover, under the assumption of independent round keys, we prove that also the KASUMI two-round functions and ...
Sparr Rüdiger, Wernsdorf Ralph
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The tensor product of m-partition algebras as a centralizer algebra of

Mathematics Open
In this paper, we concentrate on the generalized Jones result in Kennedy and Jaish (2021) which says that [Formula: see text], the tensor product of m-partition algebras is a centralizer algebra of the action of the direct product of symmetric groups ...
Amani M. Alfadhli
doaj   +1 more source

Automatic Detection of the Cyclic Alternating Pattern of Sleep and Diagnosis of Sleep-Related Pathologies Based on Cardiopulmonary Resonance Indices

Sensors, 2022
The cyclic alternating pattern is the periodic electroencephalogram activity occurring during non-rapid eye movement sleep. It is a marker of sleep instability and is correlated with several sleep-related pathologies.
Jiajia Cui, Zhipei Huang, Jiankang Wu
doaj   +1 more source

The automorphism group of the alternating group graph

Applied Mathematics Letters, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Unramified cohomology of alternating groups

Open Mathematics, 2011
Abstract We prove vanishing results for the unramified stable cohomology of alternating groups.
Bogomolov Fedor, Petrov Tihomir
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Product of conjugacy classes of complete cycles in the alternating group [PDF]

Discrete Mathematics Letters, 2022
Omar Tout
doaj   +1 more source

The alternating central extension for the positive part of Uq(slˆ2)

Nuclear Physics B, 2019
This paper is about the positive part Uq+ of the quantum group Uq(slˆ2). The algebra Uq+ has a presentation with two generators A,B that satisfy the cubic q-Serre relations. Recently we introduced a type of element in Uq+, said to be alternating.
Paul Terwilliger
doaj   +1 more source