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Beta human papillomavirus 8E6 promotes alternative end joining

open access: yeseLife, 2023
Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. The E6 protein of beta-human papillomavirus (HPV8 E6) impairs two critical DSB repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ).
Changkun Hu   +7 more
doaj   +3 more sources

Digital five-step questionnaire to enhance standard perioperative prophylaxis in surgical patients with reported allergy to beta-lactam-antibiotics [PDF]

open access: yesAntimicrobial Stewardship & Healthcare Epidemiology
Background: Most self-reported beta-lactam antibiotic (BLA) allergies are inaccurate. This study evaluated a digital tool designed to reassess beta-lactam allergies and enable the use of standard perioperative antibiotic prophylaxis (PAP) without the ...
Daniel Röder   +5 more
doaj   +2 more sources

Beta distribution misspecification tests with application to Covid-19 mortality rates in the United States

open access: yesPLoS ONE, 2022
The beta distribution is routinely used to model variables that assume values in the standard unit interval, (0, 1). Several alternative laws have, nonetheless, been proposed in the literature, such as the Kumaraswamy and simplex distributions. A natural
José Jairo Santana-e-Silva   +2 more
doaj   +2 more sources

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

open access: yesNature Communications, 2021
Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor ...
Christos Karampelias   +10 more
doaj   +1 more source

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. [PDF]

open access: yesPLoS Genetics, 2013
All pancreatic endocrine cell types arise from a common endocrine precursor cell population, yet the molecular mechanisms that establish and maintain the unique gene expression programs of each endocrine cell lineage have remained largely elusive.
Ashleigh E Schaffer   +11 more
doaj   +1 more source

Smart Beta Investing: An Alternative Investment Paradigm in Emerging Indian Equity Market

open access: yesOrganizations and Markets in Emerging Economies, 2022
This paper fundamentally looks at the novel concept of Smart Beta investing in constructing a more efficient and well-diversified alternative investment.
Reema Monga   +2 more
doaj   +1 more source

Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders. [PDF]

open access: yesPLoS ONE, 2009
BACKGROUND: Non-coding single nucleotide polymorphisms (SNPs) in GABRB2, the gene for beta(2)-subunit of gamma-aminobutyric acid type A (GABA(A)) receptor, have been associated with schizophrenia (SCZ) and quantitatively correlated to mRNA expression and
Cunyou Zhao   +11 more
doaj   +1 more source

IMPLEMENTATION OF ALTERNATIVE INDEX WEIGHTING TO WARSAW STOCK EXCHANGE

open access: yesCopernican Journal of Finance & Accounting, 2017
Exchange Traded Funds are the fastest growing segment of investment management business. Over last eleven years ETF’s AUM grew over 2,000% This paper explores growing popularity of this investment vehicle and getting to the genesis of index tracking ...
Kamil Nowak
doaj   +3 more sources

Plant species diversity and environmental factor relations in black pine, brutian pine, crimean juniper and oak forests

open access: yesTurkish Journal of Forestry, 2023
In this study, plant species diversity in Black pine, Red pine, Crimean juniper and oak forests in Dursunbey (Balıkesir) district was associated with some environmental variables and stand characteristics.
Halil İbrahim Ürkmez, Serkan Gülsoy
doaj   +1 more source

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