Results 91 to 100 of about 1,179,365 (340)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Definition of the stimulated emission threshold in high-$\beta$ nanoscale lasers through phase-space reconstruction

, 2011
Nanoscale lasers sustain few optical modes so that the fraction of spontaneous emission $\beta$ funnelled into the useful (lasing) mode is high (of the order of few 10$^{-1}$) and the threshold, which traditionally corresponds to an abrupt kink in the ...
A. Beveratos, A. Lemaitre, D. Elvira, G. L. Lippi, I. Abram, I. Robert-Philip, I. Sagnes, L. Le Gratiet, R. Braive, R. Loudon, X. Hachair   +10 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Design of a neutrino source based on beta beams

Physical Review Special Topics. Accelerators and Beams, 2014
“Beta beams” produce collimated pure electron (anti)neutrino beams by accelerating beta active ions to high energies and having them decay in a racetrack shaped storage ring of 7 km circumference, the decay ring.
E. Wildner, C. Hansen, E. Benedetto, E. Jensen, T. Stora, T. Melo Mendonca, V. Vlachoudis, E. Bouquerel, M. Marie-Jeanne, P. Balint, C. Fourel, J. Giraud, J. Jacob, T. Lamy, L. Latrasse, P. Sortais, T. Thuillier, S. Mitrofanov, M. Loiselet, Th. Keutgen, Th. Delbar, F. Debray, C. Trophime, S. Veys, C. Daversin, V. Zorin, I. Izotov, V. Skalyga, A. Chancé, J. Payet, G. Burt, A. C. Dexter, V. L. Kravchuk, T. Marchi, M. Cinausero, F. Gramegna, G. De Angelis, G. Prete, G. Collazuol, M. Mezzetto, E. Vardaci, A. Di Nitto, A. Brondi, G. La Rana, R. Moro, V. Palladino, N. Gelli, M. Mazzocco, C. Signorini, T. Y. Hirsh, M. Hass, D. Berkovits, A. Stahl, M. Schaumann, J. Wehner   +54 more
doaj   +1 more source

Archipelago reserves, a new option to protect montane entomofauna and beta-diverse ecosystems

Revista Mexicana de Biodiversidad, 2018
Beta diversity is often a dominant characteristic in mountain systems and naturally fragmented ecosystems. However, natural protected areas are traditionally designed to protect ecosystems with high alpha and low beta diversity.
Victor Moctezuma, Gonzalo Halffter, Alfonsina Arriaga-Jiménez   +2 more
doaj   +1 more source

Permanent Pacemaker Implantation with beta blocker as alternative to ICD in patients presented with Ventricular Tachycardia

, 2023
Shekharjyoti Gogoi, Pradeep Singh, Suman Prakash, H.C. Kalita, Mriganka Shekhar Chaliha   +4 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Generic bounds on dipolar gravitational radiation from inspiralling compact binaries

, 2012
Various alternative theories of gravity predict dipolar gravitational radiation in addition to quadrupolar radiation. We show that gravitational wave (GW) observations of inspiralling compact binaries can put interesting constraints on the strengths of ...
Arun K G, Arun K G, Arun K G, Arun K G, Blanchet L, Cornish N Sampson L Yunes N Pretorius F, Healy J, Jacobson T, K G Arun, Moffat J W, Sathyaprakash B S, Van Den Broeck C, Will C M, Will C M, Will C M, Yunes N Pani P Cardoso V   +15 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Is interferon-beta an alternative treatment for chronic hepatitis C

World Journal of Gastroenterology, 2006
The treatment of chronic hepatitis C (CHC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-alpha (IFNalpha) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approaches are generally associated with a
Ricardo, Moreno-Otero, María, Trapero-Marugán, Elena, Gómez-Domínguez, Luisa, García-Buey, José A, Moreno-Monteagudo   +4 more
openaire   +2 more sources