Results 121 to 130 of about 1,179,365 (340)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
AIMS MathematicsWe explored the $ AA $-iterative algorithm within the hyperbolic spaces (HSs), aiming to unveil a stability outcome for contraction maps and convergence outcomes for generalized $ (\alpha, \beta) $-nonexpansive ($ G\alpha \beta N $) maps in such spaces ...
Aynur Şahin , Zeynep Kalkan
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Emergence of Alternative Structures in Amyloid Beta 1-42 Monomeric Landscape by N-terminal Hexapeptide Amyloid Inhibitors [PDF]
, 2017 Srirupa Chakraborty, Payel Das
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
The Low-Cycle Fatigue Performance of Emerging Titanium Alloys for Aeroengine Applications
MetalsThe low-cycle fatigue behavior of three titanium alloys (including two wrought alloys that are commercially available and one under development via a powder sintering technique) is described in order to assess the relative capabilities of a fourth, novel
Peter Davies +7 more
doaj +1 more source
A congruence involving alternating harmonic sums modulo $p^{\alpha}q^{\beta}$
, 2015 In 2014, Wang and Cai established the following harmonic congruence for any odd prime $p$ and positive integer $r$, \begin{equation*} \sum\limits_{i+j+k=p^{r}\atop{i,j,k\in \mathcal{P}_{p}}}\frac{1}{ijk}\equiv-2p^{r-1}B_{p-3} ~(\bmod ~ p^{r}), \end{equation*} where $\mathcal{P}_{n}$ denote the set of positive integers which are prime to $n$.
Shen, Zhongyan, Cai, Tianxin
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source