HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells
Cells, 2021 During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR).
Vinícius M. Gomes +8 more
doaj +1 more source
Hyperations, Veblen progressions and transfinite iterations of ordinal functions
, 2012 In this paper we introduce hyperations and cohyperations, which are forms of transfinite iteration of ordinal functions. Hyperations are iterations of normal functions. Unlike iteration by pointwise convergence, hyperation preserves normality.
Fernández-Duque, David +1 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Cells, 2018 Deregulated NF-κB signalling is implicated in the pathogenesis of numerous human inflammatory disorders and malignancies. Consequently, the NF-κB pathway has attracted attention as an attractive therapeutic target for drug discovery.
Jack A. Prescott, Simon J. Cook
doaj +1 more source
Zanco Journal of Medical Sciences, 2023 Background and objective: The increased prevalence of extended- spectrum beta-lactamase producing Enterobacteriaceae has increased the use of last-resort antimicrobial drugs like Carbapenems.
Hozan Yousif Hassan +3 more
doaj +1 more source
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11[beta]-hydroxysteroid dehydrogenase 1 [PDF]
, 2008 Intracellular glucocorticoid reactivation is catalyzed by 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphate dehydrogenase (H6PDH).
Alex Odermatt +4 more
core +1 more source
Kinematical Test of Large Extra Dimension in Beta Decay Experiments
, 2013 The forthcoming experiments on neutrino mass measurement using beta decay, open a new window to explore the Large Extra Dimension model. The Kaluza-Klein tower of neutrinos in Large Extra Dimension contribute to the Kurie function of beta decay that can ...
Antoniadis +38 more
core +1 more source
Heterotic/Heterotic Duality in D=6,4 [PDF]
, 1996 We consider $E_8\times E_8$ heterotic compactifications on $K3$ and $K3\times T^2$. The idea of heterotic/heterotic duality in $D=6$ has difficulties for generic compactifications since for large dilaton values some gauge groups acquire negative kinetic ...
A. Font +33 more
core +2 more sources
Enhancement of Yield, Phytochemical Content and Biological Activity of a Leafy Vegetable (Beta vulgaris L. var. cycla) by Using Organic Amendments as an Alternative to Chemical Fertilizer [PDF]
, 2023 Angela Libutti +5 more
openalex +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source