Results 71 to 80 of about 1,179,365 (340)

Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.
Athena L.V. Hobbs, Vagish S. Hemmige, Katie L. Reel, Theresa C. Jaso, Dusten T. Rose, Katherine M. Shea   +5 more
doaj   +1 more source

Performance of several types of beta-binomial models in comparison to standard approaches for meta-analyses with very few studies

BMC Medical Research Methodology, 2022
Background Meta-analyses are used to summarise the results of several studies on a specific research question. Standard methods for meta-analyses, namely inverse variance random effects models, have unfavourable properties if only very few (2 – 4 ...
Moritz Felsch, Lars Beckmann, Ralf Bender, Oliver Kuss, Guido Skipka, Tim Mathes   +5 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

An alternative proof of a harmonic mean inequality for Nielsen’s beta function [PDF]

Contributions to Mathematics, 2021
Kwara Nantomah
doaj   +1 more source

Functional activities of beta-glucans in the prevention or treatment of cervical cancer

Journal of Ovarian Research, 2020
Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches in the treatment of cervical cancer, but because of their side
Shahla Chaichian, Bahram Moazzami, Fatemeh Sadoughi, Hamed Haddad Kashani, Marsa Zaroudi, Zatollah Asemi   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Project management under uncertainty beyond beta: The generalized bicubic distribution

Operations Research Perspectives, 2016
The beta distribution has traditionally been employed in the PERT methodology and generally used for modeling bounded continuous random variables based on expert’s judgment.
José García Pérez, María del Mar López Martín, Catalina García García, Miguel Ángel Sánchez Granero   +3 more
doaj   +1 more source

Relic neutrino detection through angular correlations in inverse $\beta$-decay

, 2019
Neutrino capture on beta-decaying nuclei is currently the only known potentially viable method of detection of cosmic background neutrinos. It is based on the idea of separation of the spectra of electrons or positrons produced in captures of relic ...
Akhmedov, Evgeny
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source