Results 51 to 60 of about 100,863 (253)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Winter Wheat Row Spacing and Alternative Crop Effects on Relay-Intercrop, Double-Crop, and Wheat Yields

International Journal of Agronomy, 2015
In Missouri as well as much of the Midwest, the most popular double-cropping system was winter wheat (Triticum aestivum L.) followed by soybean (Glycine max (L.) Merr).
Leah Sandler, Kelly A. Nelson, Christopher Dudenhoeffer   +2 more
doaj   +1 more source

Temporal Dynamics of Host Use by Drosophila suzukii in California’s San Joaquin Valley: Implications for Area-Wide Pest Management

Insects, 2019
A major challenge to the area-wide management of Drosophila suzukii is understanding the fly’s host use and temporal dynamics, which may dictate local movement patterns. We determined D.
Xingeng Wang, Gülay Kaçar, Kent M. Daane   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Diversification and Management Practices in Selected European Regions. A Data Analysis of Arable Crops Production

Agronomy, 2020
In the European Union, various crop diversification systems such as crop rotation, intercropping and multiple cropping, as well as low-input management practices, have been promoted to sustain crop productivity while maintaining environmental quality and
Rosa Francaviglia, Jorge Álvaro-Fuentes, Claudia Di Bene, Lingtong Gai, Kristiina Regina, Eila Turtola   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Assessing the Economic Impacts of Pesticide Regulations

Agriculture, 2018
Economic impacts of pesticide regulations are assessed using five alternative methodologies. The regulations include crop supply-enhancing eradication programs and crop supply-decreasing pesticide bans.
Uwe A. Schneider, Livia Rasche, Bruce A. McCarl   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Grain Amaranth as an Alternative and Perspective Crop in Temperate Climate

Revija za Geografijo, 2010
As a consequence of globalisation and industrialisation of agriculture, global food security has become increasingly dependent on only a handful of fertilisation and energy high demanding plant species.
Silva Grobelnik Mlakar, Matjaž Turinek, Manfred Jakop, Martina Bavec, Franc Bavec   +4 more
doaj   +1 more source