Results 61 to 70 of about 738,723 (261)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Techno-Economic Study of 100% Renewable Energy for a Residential Household in China

Energies, 2019
In the context of global warming and energy shortage, this paper discusses the techno-economic feasibility of a residential household based on 100% renewable energy in China.
Zhe Lv, Zengping Wang, Wanyu Xu
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluating the economic and environmental viability of hybrid solar-geothermal heat pump systems in Jordan using multi-criteria decision analysis

Discover Sustainability
Jordan is currently facing an energy crisis characterized by a heavy dependence on imported fossil fuels, prompting the nation to target a 50% share of renewable energy by 2030. This study introduces a novel approach by simulating hybrid solar-geothermal
Malik Alamayreh, Yousef Altork
doaj   +1 more source

Improved time-domain distance protection based on fault active control for long transmission lines of PV/BES hybrid power generation system

International Journal of Electrical Power & Energy Systems
The fault current of the photovoltaic (PV)/battery energy storage (BES) hybrid power generation system contains harmonic components, which might cause the maloperation of the distance relay.
Tao Zheng, Ruozhu Zhang, Wenxuan Lv, Sen Liu   +3 more
doaj   +1 more source

Alternative Energy for Energy Sustainability

Annals of Arid Zone, 2016
Energy has become a part and parcel of human survival and societal progress. In fact, per capita energy consumption has become a measure of a nation's progress. Just as air, water and food are the most important materials required for the survival of human life on earth, energy is essential for sustenance of the human race.
B.G Shiva Prasad, Kal Renganathan Sharma
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Self-assembled hole-selective contact for efficient Sn-Pb perovskite solar cells and all-perovskite tandems

Nature Communications
Self-assembled monolayers (SAMs) have displayed unpredictable potential in efficient perovskite solar cells (PSCs). Yet most of SAMs are largely suitable for pure Pb-based devices, precisely developing promising hole-selective contacts (HSCs) for Sn ...
Jingwei Zhu, Xiaozhen Huang, Yi Luo, Wenbo Jiao, Yuliang Xu, Juncheng Wang, Zhiyu Gao, Kun Wei, Tianshu Ma, Jiayu You, Jialun Jin, Shenghan Wu, Zhihao Zhang, Wenqing Liang, Yang Wang, Shengqiang Ren, Changlei Wang, Cong Chen, Jinbao Zhang, Dewei Zhao   +19 more
doaj   +1 more source