Results 51 to 60 of about 738,723 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Simulation of reactivity-initiated accident transients on UO2-M5® fuel rods with ALCYONE V1.4 fuel performance code

Nuclear Engineering and Technology, 2018
The ALCYONE multidimensional fuel performance code codeveloped by the CEA, EDF, and AREVA NP within the PLEIADES software environment models the behavior of fuel rods during irradiation in commercial pressurized water reactors (PWRs), power ramps in ...
Isabelle Guénot-Delahaie, Jérôme Sercombe, Thomas Helfer, Patrick Goldbronn, Éric Fédérici, Thomas Le Jolu, Aurore Parrot, Christine Delafoy, Christian Bernaudat   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synthesis of titanium (IV) oxide composite membrane for hydrogen production through alkaline water electrolysis

South African Journal of Chemical Engineering, 2018
Alkaline water electrolysis is one of the most efficient methods for the hydrogen production. In this method widely used as the asbestos membrane as a separator, but this material is hazardous for health, causing cancer, in order to limit the usage of an
S. Shiva Kumar, S.U.B. Ramakrishna, S. Vijaya Krishna, K. Srilatha, B. Rama Devi, V. Himabindu   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alternative Energy: Future Energy

Journal of Industrial Technology and Innovation, 2022
พลังงาน เป็นความสามารถในการทำงานหรือทำให้เกิดงาน ผลการทำงานของแรงนั้นทำให้วัตถุหรือสิ่งใด ๆ เคลื่อนที่ หรือเคลื่อนไหว พลังงานนั้นสามารถจัดเก็บไว้ได้พลังงานไม่สามารถถูกทำลายได้ แต่สามารถเปลี่ยนแปลงจากรูปหนึ่งไปเป็นอีกรูปหนึ่งได้  เช่น พลังงานจลน์ พลังงานศักย์พลังงานกล พลังงานไฟฟ้า พลังงานความร้อน พลังงานชีวะ พลังงานน้ำ พลังงานความร้อนใต้พิภพ พลังงานลม ...
openaire   +1 more source