Results 71 to 80 of about 30,287 (233)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Healthy dietary patterns, biological aging, and kidney stones: evidence from NHANES 2007–2018

Frontiers in Nutrition
BackgroundThis study aims to investigate the comprehensive association between healthy dietary patterns, biological aging, and kidney stones in a large population-based cohort.MethodsWe analyzed data from 6 cycles of NHANES surveys from 2007 to 2018 and ...
Chengcheng Wei, Qian Yang, Qian Yang, Jingke He, Yu Luo, Kun Han, Junkun Li, Shuai Su, Shuai Su, Jindong Zhang, Hongxing Wang, Hongxing Wang, Delin Wang   +12 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Sex-specific associations between diet quality and mortality in adults with diabetes: findings from NHANES 2001-2018

Frontiers in Nutrition
ObjectiveTo investigate the impact of diet on cardiovascular (CV)/all-cause mortality among individuals with diabetes, and to explore whether this relationship changes by gender.MethodsWe collected data from the National Health and Nutrition Examination ...
Zhang Youqi, Zhang Youqi, Yan Meng, Ji Liu, Wu Jianjun, Yang Fan, Yang Fan   +6 more
doaj   +1 more source

A review on indexes and dietary assessment methods for determining the quality of diets - doi:10.5020/18061230.2011.p404

Revista Brasileira em Promoção da Saúde, 2012
Objective: To summarize the different indexes most frequently used to evaluate the quality of diets, as well as the dietary assessment methods used for scoring, pointing out their advantages and disadvantages.
Ana Carolina Pinheiro Volp
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Which dietary pattern should be adopt by age-appropriate pregnant women to avoid gestational weight gain and gestational diabetes mellitus

BMC Pregnancy and Childbirth
Background Gestational weight gain (GWG) and gestational diabetes mellitus (GDM), as two major adverse pregnancy outcomes, could be affected by diet patterns, and GWG also influenced GDM.
Yan Li, Hui Zheng, Weiyu Jiang, Yang Chi, Yizi Meng, Yanxiang Mo, Chen Chen, Bo Qu, Jin He, Feng Chen   +9 more
doaj   +1 more source

Does dietary intake change during an intervention to reduce sedentary behavior and cardiovascular disease risk? A randomized comparative effectiveness trial

BMC Nutrition, 2018
Background Evidence from physical activity interventions suggests that women, in particular, may overcompensate for exercise energy expenditure by increasing caloric intake.
Kelsey Casey, Emily L. Mailey, Richard R. Rosenkranz, Aaron Swank, Elizabeth Ablah, Sara K. Rosenkranz   +5 more
doaj   +1 more source