Toward the use of novel alternative methods in epilepsy modeling and drug discovery [PDF]
Frontiers in Neurology, 2023 Epilepsy is a chronic brain disease and, considering the amount of people affected of all ages worldwide, one of the most common neurological disorders.
Claudia Miguel Sanz +4 more
doaj +2 more sources
Alternative Methods for Skin-Sensitization Assessment. [PDF]
Toxics, 2022 Gądarowska D +3 more
europepmc +2 more sources
A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation
Frontiers in Immunology, 2023 We have integrated dermal dendritic cell surrogates originally generated from the cell line THP-1 as central mediators of the immune reaction in a human full-thickness skin model.
Johanna Maria Hölken +8 more
doaj +1 more source
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1
Toxins, 2021 The application of botulinum neurotoxins (BoNTs) for medical treatments necessitates a potency quantification of these lethal bacterial toxins, resulting in the use of a large number of test animals.
Maren Schenke +6 more
doaj +1 more source
Toxic Indoor Air Is a Potential Risk of Causing Immuno Suppression and Morbidity—A Pilot Study
Journal of Fungi, 2022 We aimed to establish an etiology-based connection between the symptoms experienced by the occupants of a workplace and the presence in the building of toxic dampness microbiota. The occupants (5/6) underwent a medical examination and urine samples (2/6)
Kirsi Vaali +4 more
doaj +1 more source
Methods and Protocols, 2022 In order to improve a recently established cell-based assay to assess the potency of botulinum neurotoxin, neuroblastoma-derived SiMa cells and induced pluripotent stem-cells (iPSC) were modified to incorporate the coding sequence of a reporter ...
Brit-Maren Michaud Schjeide +3 more
doaj +1 more source
Antibacterial Activity of the Pyrogallol against Staphylococcus aureus Evaluated by Optical Image
Biologics, 2022 The minimum inhibitory concentration (MIC) is used to define the lowest concentration at which a substance can inhibit bacterial growth. This study aimed to evaluate the MIC of pyrogallol against Staphylococcus aureus and to propose a method for building
Lígia C. C. Oliveira +7 more
doaj +1 more source
Hourly reference evapotranspiration by Moretti-Jerszurki-Silva method using data from alternative station [PDF]
Revista Brasileira de Engenharia Agrícola e Ambiental, 2021 Reliable measures of climate variables and the availability of alternative and safe methods are fundamental in estimating reference evapotranspiration (ETo) under unfavorable technical and financial conditions. The objective of this study was to evaluate
Jorge L. M. de Souza +3 more
doaj +1 more source
Qualitative methods: an alternative view [PDF]
BMJ, 2011 Are qualitative and quantitative research really based on different philosophies? John Paley and Richard Lilford argue that the idea that qualitative research is constructivist should not be allowed to diffuse into medical literature unopposed.
Paley, John, Lilford, Richard J
openaire +3 more sources
The Skin Sensitisation of Cosmetic Ingredients: Review of Actual Regulatory Status
Toxics, 2023 All cosmetics products must be safe under foreseeable conditions of use. Allergenic responses are one of the most frequent adverse reactions noted for cosmetics.
Iwona Bialas +2 more
doaj +1 more source