Results 91 to 100 of about 6,945,821 (305)

Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology

open access: yesFrontiers in Toxicology
IntroductionAnimal studies have historically informed toxicological testing and safety assessments. However, assessment of the variability in both quantitative and qualitative results has been limited.
Agnes L. Karmaus   +8 more
doaj   +1 more source

LHC top mass: alternative methods and prospects for the future

open access: yes, 2014
Future lepton colliders will have a rich top quark physics program which would add to our understanding of this interesting quark and promise an ultimate precision on the experimental knowledge of top-quark mass.
Kim, Min Suk
core  

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents

open access: yesToxics
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Ricardo Scheufen Tieghi   +8 more
doaj   +1 more source

Alternative methods of solving state-dependent pricing models [PDF]

open access: yes
We use simulation-based techniques to compare and contrast two methods for solving state-dependent pricing models: discretization, which solves and simulates the model on a grid; and collocation, which relies on Chebyshev polynomials.
Edward S. Knotek II, Stephen Terry
core  

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

Scientific Opinion on Bioreduction application

open access: yesEFSA Journal, 2013
A method for on‐farm containment of animal by‐products (ABPs), called a ‘Bioreduction’ system, was assessed. The material for containment is of ovine origin and classified as a Category (Cat.) 1 ABP material.
EFSA Panel on Biological Hazards (BIOHAZ)
doaj   +1 more source

Methods for the evaluation of alternative disaster warning systems [PDF]

open access: yes
For each of the methods identified, a theoretical basis is provided and an illustrative example is described. The example includes sufficient realism and detail to enable an analyst to conduct an evaluation of other systems.
Agnew, C. E.   +2 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Alternative Methods of Increasing the Precision of Weighted Repeat Sales House Prices Indices* [PDF]

open access: yes, 2004
Weighted repeat sales house price indices have become one of the primary indicators used to identify housing market conditions and to estimate the amount of equity homeowners have gained through house price appreciation.
Dreiman, Michelle H   +1 more
core   +1 more source

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