Results 131 to 140 of about 6,945,821 (305)

EVALUATING ALTERNATIVE METHODS OF DEALING WITH MISSING OBSERVATIONS - AN ECONOMIC APPLICATION [PDF]

This paper compares methods to remedy missing value problems in survey data. The commonly used methods to deal with this issue are to delete observations that have missing values (case-deletion), replace missing values with sample mean (mean imputation),
Onozaka, Yuko
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Alternative methods to measure breast density in younger women. [PDF]

Br J Cancer, 2023
Lloyd R, Pirikahu S, Walter J, Cadby G, Darcey E, Perera D, Hickey M, Saunders C, Karnowski K, Sampson DD, Shepherd J, Lilge L, Stone J.   +12 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dissection in biology education compared to alternative methods in terms of their influence on students' emotional experience. [PDF]

Front Psychol, 2023
Kaiser LM, Polte S, Kirchhoff T, Großmann N, Wilde M.   +4 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Validation of skinfold equations and alternative methods for the determination of fat-free mass in young athletes. [PDF]

Front Sports Act Living, 2023
Jagim AR, Tinsley GM, Merfeld BR, Ambrosius A, Khurelbaatar C, Dodge C, Carpenter M, Luedke J, Erickson JL, Fields JB, Jones MT.   +10 more
europepmc   +1 more source

Poverty targeting in public programs: A comparison of alternative nonparametric methods [PDF]

Very poor households may be excluded from public programs intended for their benefit for a variety of reasons as lack information, a permanent residence or membershiip in social networks.
Isha Dewan, Rohini Somanathan
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. [PDF]

J Biomed Semantics, 2023
Neves M, Klippert A, Knöspel F, Rudeck J, Stolz A, Ban Z, Becker M, Diederich K, Grune B, Kahnau P, Ohnesorge N, Pucher J, Schönfelder G, Bert B, Butzke D.   +14 more
europepmc   +1 more source