Results 151 to 160 of about 6,945,821 (305)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Usage of Complementary and Alternative Methods, Lifestyle, and Psychological Variables in Cancer Care. [PDF]

In Vivo, 2023
Hoppe C, Buntzel J, VON Weikersthal LF, Junghans C, Zomorodbakhsch B, Stoll C, Prott FJ, Fuxius S, Micke O, Richter A, Sallmann D, Hubner J.   +11 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

MULTIDIMENSIONAL OUTPUT INDICES [PDF]

This abstract describes alternative output aggregates that provide both cross-sectional and temporal comparisons appropriate for the analysis of panel data sets.
Craig, Barbara J., Pardey, Philip G.
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review. [PDF]

Food Chem Toxicol, 2023
Shin HK, Huang R, Chen M.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evaluating alternative methods of comparing antihypertensive treatment intensity. [PDF]

Am J Manag Care, 2022
Aubert CE, Chan CL, Terman SW, Hofer TP, Ha JK, Cushman WC, Sussman J, Min L.   +7 more
europepmc   +1 more source

Alternative methods and citizen science

ALTEX, 2022
F. Caloni, P. Fossati, T. Hartung, P Martino, G. Mormino, A. Vitale, I. De Angelis   +6 more
openaire   +4 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source