Results 151 to 160 of about 8,418,894 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Passenger-Oriented Enhanced Metrics [PDF]
, 2012 We report on a project building the first European ATM simulation combining flight and passenger trip data. New propagation-centric and passenger-centric performance metrics are described. The new metrics will be compared with existing, classical metrics,
Cook, A.J. +3 more
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Alternative Metric-Clock Cosmology
This alternative cosmological model proposes a reinterpretation of the universe's apparent expansion by introducing a variable Planck length that decreases over time. Rather than attributing redshift solely to metric expansion, the model suggests that fundamental units of measurement evolve, which results in an apparent cosmological expansion when ...
openaire +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On series with alternating signs in the Euclidean metric
, 1999 Series of the form \[ \sum_{n=1}^\infty(-1)^{a_n} b_n\tag{1} \] are studied, where \((a_n)_1^\infty\in \{0,1\}^{\mathbb{N}}\), \(b_n\) are elements of a real Hilbert space. Mainly the structure of the sets \(C= \{(a_n)_1^\infty\in \{0,1\}^{\mathbb{N}}\): (1) converges\}, \(B= \{(a_n)_1^\infty\in \{0, 1\}^{\mathbb{N}}\): (1) is bounded\} are ...
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
QUALITY METRICS FOR IT PROJECT MANAGEMENT [PDF]
Using metrics and indicators for the evaluation of the IT projects management have the advantage of providing rigorous details about the required effort and the boundaries of the IT deliverables. There are some disadvantages, as well, due to the fact the
Radu MARSANU +2 more
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Pacific Centre for Alternative Journalists
, 1999 A pamphlet describing the Centre, its objectives and goals, a brief outline of plans for Spring mini-courses, and contact ...
Pacific Centre for Alternative Journalists
core +1 more source
Office of Innovative Partnerships & Alternative Funding as of December 30, 2011 [PDF]
, 2011 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 1, 2014)Mode of ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source