Results 131 to 140 of about 8,418,894 (311)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Development and sensitivity testing of alternative mobility metrics: literature review [PDF]

, 2010
The Oregon Department of Transportation (ODOT) manages the state highway system under the guidance of the 1999 Oregon Highway Plan (OHP) (ODOT 1999). Among other things, OHP policies and actions emphasize efficient use of limited resources. This emphasis,

core  

Analysis of classification metric behaviour under class imbalance

Egyptian Informatics Journal
Class imbalance is the phenomenon defined as skewed target variable distributions in a dataset. In other words class imbalance occurs when a dataset has an unequal proportion of target variables assigned to the instances in the dataset.
Jean-Pierre van Zyl, Andries Petrus Engelbrecht   +1 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Eigenvalue bounds and alternating rank-metric codes

Journal of Algebra and Its Applications
In this note, we apply a spectral method to the graph of alternating bilinear forms. In this way, we obtain upper bounds on the size of an alternating rank-metric code for given values of the minimum rank distance. We computationally compare our results with Delsarte’s linear programming bound, observing that they give the same value.
Aida Abiad, Gianira N. Alfarano, Alberto Ravagnani   +2 more
openaire   +3 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

An Alternative Variational Principle for Geodesics of a Randers Metric

Advanced Nonlinear Studies, 2009
Abstract We present an alternative variational principle for the geodesics of a Randers metric. We define a functional I on the manifold of H 1,2 curves joining two points on a Randers manifold (M, F) defined by a Riemannian metric g and a differential form ω. The functional
openaire   +3 more sources

Metric-Driven Voronoi Diagrams: A Comprehensive Mathematical Framework

Computation
Voronoi partitioning is a fundamental geometric concept with applications across computational geometry, robotics, optimization, and resource allocation.
Vishnu G. Nair
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source