Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Erratum: Viability of AMURA biomarkers from single-shell diffusion MRI in clinical studies
Frontiers in Neuroscience, 2023 Frontiers Production Office
doaj +1 more source
Recommending Refactoring Solutions Based on Traceability and Code Metrics
IEEE Access, 2018 Software refactoring has been extensively used to rectify the design flaws and improve software quality without affecting its observable behaviors. For a given code smell, it is common that there exist multiple refactoring solutions.
Ally S. Nyamawe +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Two new feature selection metrics for text classification
Automatika, 2019 Obtaining meaningful information from data has become the main problem. Hence data mining techniques have gained importance. Text classification is one of the most commonly studied areas of data mining.
Durmuş Özkan Şahin, Erdal Kılıç
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Mapping the Generations of Research Impact Science: A Scoping Review of Metrics, Frameworks, and Predictive Approaches [PDF]
Journal of Library and Information StudiesThis scoping review systematically examines the evolution of research impact assessment frameworks, categorising their development into 4 generations.
Mudassar Arsalan +2 more
doaj +1 more source
Ecological and economic implications of alternative metrics in biodiversity offset markets. [PDF]
Conserv Biol, 2022 Simpson KH +4 more
europepmc +1 more source