Results 41 to 50 of about 32,274 (243)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparing the clinical utility of the alternative model for personality disorders to the Section II personality disorder model: A randomized controlled trial.

Personality Disorders: Theory, Research, and Treatment
The alternative model for personality disorders (AMPD) has been extensively studied over the past decade, but to date there is no direct comparison of the clinical utility of the AMPD model relative to the Section II personality disorder (PD) model in an ecologically valid design.
Laura C. Weekers, Joost Hutsebaut, Hilde De Saeger, Jan H. Kamphuis   +3 more
openaire   +3 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Conceptualizing adult ADHD with the DSM Alternative Model of Personality Disorder

Personality and Mental Health
Personality traits and personality disorders are related to ADHD and to indicate dysfunction in clinical populations. The goals of this study were to examine how the DSM-5 Alternative Model of Personality Disorder (AMPD) a) indicate presence of ADHD and b) communicate information about dysfunction over and above ADHD diagnosis.
Peter Jacobsson, Christopher James Hopwood, Robert Krueger, Bo Soderpalm, Thomas Nilsson   +4 more
openaire   +3 more sources

Changes in the classification of personality disorders: Comparing the DSM–5 Section II personality disorder model to the alternative model for personality disorders using structured clinical interviews.

Personality Disorders: Theory, Research, and Treatment, 2022
The current study examined the continuity of personality disorder (PD) diagnoses from Section II to Section III (alternative model for personality disorders [AMPD]) when using structured interviews. We investigated the continuity both in terms of stability of prevalence rates and in terms of convergent validity.
Laura C. Weekers, Joost Hutsebaut, Johannes Zimmermann, Jan H. Kamphuis   +3 more
openaire   +4 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Personality Constructs and Paradigms in the Alternative DSM-5 Model of Personality Disorder [PDF]

Journal of Personality Assessment, 2018
The DSM-5 Section III alternative model for personality disorders (AMPD) is a personality disorder (PD) nosology based on severity of personality dysfunction and pathological traits. We examined the degree to which the personality constructs identified by McAdams and Pals (2006; dispositional traits, characteristic adaptations, narrative identity) and ...
Mulay, Abby L, Cain, Nicole M, Waugh, Mark H, Hopwood, Christopher J, Adler, Jonathan M, Garcia, Darren J, Kurtz, John E, Lenger, Katherine A, Skadberg, Rebecca   +8 more
openaire   +5 more sources

Measurement invariance of the Personality Inventory for DSM-5 across sex

Frontiers in Psychiatry
IntroductionThere has been an international movement towards dimensional models of personality disorders (PDs) in the last decades, which culminated in the publication of the Alternative Model of Personality Disorders (AMPD) in the Emerging Measures and ...
Geneviève Rivard, Geneviève Rivard, Yann Le Corff, Yann Le Corff, Yann Le Corff, Mélanie Lapalme, Mélanie Lapalme, Karine Forget, Karine Forget   +8 more
doaj   +1 more source

Personality functioning in anxiety disorders

BMC Psychiatry, 2018
Background The Alternative DSM-5 Model for Personality Disorders as well as the upcoming IDC-11 have established a new focus on diagnosing personality disorders (PD): personality functioning.
Stephan Doering, Victor Blüml, Karoline Parth, Karin Feichtinger, Maria Gruber, Martin Aigner, Hemma Rössler-Schülein, Marion Freidl, Antonia Wininger   +8 more
doaj   +1 more source