Results 41 to 50 of about 32,430 (245)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A comparison of borderline personality features and level of personality functioning in explaining mentalizing capacity

Borderline Personality Disorder and Emotion Dysregulation
Background Numerous studies have demonstrated that the Alternative Model for Personality Disorders (AMPD) outperforms traditional categorical nosology (i.e., Section II) in predicting an array of salient clinical outcomes. However, despite the centrality
Charlotte S. Zell, Kennedy M. Balzen, Joseph Boudreaux, Francesca Penner, Carla Sharp   +4 more
doaj   +1 more source

The Connections between Pathological Personality Traits and Interpersonal Behavior

Psychological Topics, 2017
An alternative model of pathological personality traits was recently developed in an effort to address the challenges associated with the categorical model of personality disorder classification (e.g., high rates of comorbidity, minimal overlap with ...
Gillian A. McCabe, Jennifer K. Vrabel, Virgil Zeigler-Hill   +2 more
doaj   +2 more sources

Conceptualizing adult ADHD with the DSM Alternative Model of Personality Disorder

Personality and Mental Health
Personality traits and personality disorders are related to ADHD and to indicate dysfunction in clinical populations. The goals of this study were to examine how the DSM-5 Alternative Model of Personality Disorder (AMPD) a) indicate presence of ADHD and b) communicate information about dysfunction over and above ADHD diagnosis.
Peter Jacobsson, Christopher James Hopwood, Robert Krueger, Bo Soderpalm, Thomas Nilsson   +4 more
openaire   +3 more sources

Changes in the classification of personality disorders: Comparing the DSM–5 Section II personality disorder model to the alternative model for personality disorders using structured clinical interviews.

Personality Disorders: Theory, Research, and Treatment, 2022
The current study examined the continuity of personality disorder (PD) diagnoses from Section II to Section III (alternative model for personality disorders [AMPD]) when using structured interviews. We investigated the continuity both in terms of stability of prevalence rates and in terms of convergent validity.
Laura C. Weekers, Joost Hutsebaut, Johannes Zimmermann, Jan H. Kamphuis   +3 more
openaire   +4 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Attachment, Mentalization, and Criterion B of the Alternative DSM-5 Model for Personality Disorders (AMPD)

Borderline Personality Disorder and Emotion Dysregulation, 2021
Background The mentalization theory posits that interpersonal difficulties and maladaptive personality traits develop from an insecure attachment pattern with one’s caregiver and corresponding deficits in mentalizing—the ability to understand others’ and
Ericka Ball Cooper, Jaime L. Anderson, Carla Sharp, Hillary A. Langley, Amanda Venta   +4 more
doaj   +1 more source

Personality Constructs and Paradigms in the Alternative DSM-5 Model of Personality Disorder [PDF]

Journal of Personality Assessment, 2018
The DSM-5 Section III alternative model for personality disorders (AMPD) is a personality disorder (PD) nosology based on severity of personality dysfunction and pathological traits. We examined the degree to which the personality constructs identified by McAdams and Pals (2006; dispositional traits, characteristic adaptations, narrative identity) and ...
Mulay, Abby L, Cain, Nicole M, Waugh, Mark H, Hopwood, Christopher J, Adler, Jonathan M, Garcia, Darren J, Kurtz, John E, Lenger, Katherine A, Skadberg, Rebecca   +8 more
openaire   +5 more sources

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source