Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Beyond traditional defenses: Unraveling the dynamics of reserves and exchange rate volatility in the face of economic sanctions [PDF]
Russian Journal of EconomicsThis study investigates the impact of economic sanctions on exchange rate volatility, with a specific focus on the role of foreign reserves in mitigating these effects across 21 countries from 2002 to 2022.
Ahmed Alwadeai +3 more
doaj +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The application of international economic sanctions: the united nations, European community and 'Yugoslavia' [PDF]
, 1993 The thesis is concerned with the international mechanism for the imposition and implementation of economic sanctions and the role of the European Community within it. Chapter 1 examines the classification of responses available to States to violations of
Cole, Stephen
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Sanctions on South Africa: What Did They Do [PDF]
This paper considers the economic sanctions that were applied in the mid-1980s to pressure the South African government to end apartheid. It asks what role those sanctions played in the eventual demise of the apartheid regime and concludes that the role ...
Philip I. Levy
core
Due Process and Unilateral Targeted Sanctions
, 2023 This chapter discusses due process protections afforded to persons subject to unilateral targeted sanctions in the EU, US and UK. Based on an analysis of respective legislation and case law, it considers how unilateral targeted sanctions are imposed and ...
Moiseienko, Anton
core +1 more source
The punitive sanction as an alternative to the criminal sanction in regulatory offences
, 2001 Bibliography: p. 150-162.
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Imposed Benefit Sanctions and the Unemployment-to-Employment Transition: The German Experience [PDF]
We analyze the effect of imposed benefit sanctions on the unemployment-to-employment transition of unemployed people entitled to unemployment compensation on the basis of register data from the German Federal Employment Agency.
Kai-Uwe Müller, Viktor Steiner
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