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CK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells. [PDF]

open access: yesJ Biol Chem
Sun Q   +12 more
europepmc   +1 more source

Alternative splicing is a driving force that tunes metabolic adaptations to virulence traits in the dermatophyte <i>Trichophyton rubrum</i>. [PDF]

open access: yesFront Cell Infect Microbiol
Lopes MER   +5 more
europepmc   +1 more source
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The physiology of alternative splicing

Nature Reviews Molecular Cell Biology, 2022
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of this complexity is reflected at the protein level and fundamentally shapes the physiology and pathology of organisms.
Luciano E. Marasco   +1 more
openaire   +3 more sources

Function of alternative splicing [PDF]

open access: possibleGene, 2005
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which primarily regulates the amount of transcripts, alternative splicing changes the structure of transcripts and their encoded proteins.
Shani Ben-Ari   +7 more
openaire   +2 more sources

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