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Alternative splicing in plants
Biochemical Society Transactions, 2008The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression and proteome complexity. In plants, AS is of growing importance as more genes are found to undergo AS, but relatively little is known about the factors regulating AS or the consequences of AS on mRNA levels and protein function.
Simpson, Craig G. +10 more
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Alternative splicing and evolution
BioEssays, 2003AbstractAlternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced ...
Stéphanie Boué +2 more
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Alternative Splicing in Disease
2007Alternative splicing is a major source of diversity in the human proteome. The regulation of alternative splicingmodulates the composition of this diversity to fulfill the physiological requirements of a cell. When control of alternative splicing is disrupted, the result can be a failure to meet cellular and tissue requirements resulting in dysfunction
James P. Orengo, Thomas A. Cooper
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Alternative splicing in the testes
Current Opinion in Genetics & Development, 2002Germ-cell differentiation is an ideal process for studying the effects of alternative splicing and there are examples of alternative splicing of genes involved in gene regulation and signal transduction at every stage of the spermatogenic pathway. A network of testes-specific splicing factor interactions has been uncovered and combining our knowledge ...
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Alternative Splicing of Amelogenins
Connective Tissue Research, 1995Amelogenins comprise as much as 90% of the protein in the developing enamel matrix. Separating amelogenins by gel electrophoresis reveals a complex of polypeptides with apparent mobilities ranging from low molecular weight species on up to 28,000 Daltons.
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Predicting Alternative Splicing
2014Alternative splicing of pre-mRNA is a complex process whose outcome depends on elements reviewed in the previous chapters such as the core spliceosome units, how the core spliceosome units interact between themselves and with other splicing enhancers and repressors, primary sequence motifs, and local RNA secondary structure.
Yoseph Barash, Jorge Vaquero Garcia
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Alternative splicing in ascomycetes
Applied Microbiology and Biotechnology, 2013Alternative splicing is a complex and regulated process, which results in mRNA with different coding capacities from a single gene. Extend and types of alternative splicing vary greatly among eukaryotes. In this review, I focus on alternative splicing in ascomycetes, which in general have significant lower extend of alternative splicing than mammals ...
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Regulation of Alternative Splicing
1990With careful study of the array of RNAs produced by many different genes, it has become clear that alternative splicing is an important mechanism for the regulation of the synthesis of various biologically important proteins. The simplest form of such regulation results from the tissue- or temporal-specific splicing events that lead alternatively to ...
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Alternative transcription and alternative splicing in cancer
Pharmacology & Therapeutics, 2012In recent years, the notion of "one gene makes one protein that functions in one signaling pathway" in mammalian cells has been shown to be overly simplistic. Recent genome-wide studies suggest that at least half of the human genes, including many therapeutic target genes, produce multiple protein isoforms through alternative splicing and alternative ...
Ravi Gupta +2 more
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Alternative splicing in Alzheimer’s disease
Aging Clinical and Experimental Research, 2019Alzheimer's disease (AD) is the most frequent neurodegenerative disorder in the elderly, occurring in approximately 20% of people older than 80. The molecular causes of AD are still poorly understood. However, recent studies have shown that Alternative Splicing (AS) is involved in the gene expression reprogramming associated with the functional changes
Biamonti G +6 more
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