Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Complementary and Alternative Therapies for Genitourinary Syndrome of Menopause : An Evidence Map. [PDF]
Ullman KE +11 more
europepmc +1 more source
Alternative therapies for Covid-19. [PDF]
Sundararajan G +3 more
europepmc +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Exploring men's cancer journeys in Norway: a comprehensive survey on diet, supplements, and use of complementary and alternative therapies. [PDF]
Kristoffersen AE +5 more
europepmc +1 more source
Editorial: Complementary/Alternative Therapies for Epilepsy and Related Psychiatric Comorbidities. [PDF]
Xu Z, Wang Y, Moutal A.
europepmc +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Editorial: Complementary and alternative therapies for sleep disorders: from bench to bedside. [PDF]
Yue J +9 more
europepmc +1 more source
Performing 'pragmatic holism':professionalisation and the holistic discourse of non-medically qualified acupuncturists and homeopaths in the United Kingdom [PDF]
Givati, Assaf
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source

