Results 151 to 160 of about 9,042,320 (297)

Newly isolated <i>Pakpunavirus</i>: efficacy and safety assessment in light of alternative therapies against <i>P. aeruginosa</i> skin infections. [PDF]

Front Microbiol
Necel A, Stasiłojć M, Wesołowski W, Narajczyk M, Kosznik-Kwaśnicka K, Kaźmierczak N, Naumiuk Ł, Loika H, Piechowicz L, Żywicka A.   +9 more
europepmc   +1 more source

Methicillin-Resistant Staphylococcus aurous: Epidemiology, Transmission and New Alternative Therapies: A Narrative Review. [PDF]

Iran J Public Health, 2023
Bouali N, Haddaji N, Hamadou WS, Ghorbel M, Bechambi O, Mahdhi A, Snoussi M.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Editorial: Biofilm-mediated nosocomial infections and its association with antimicrobial resistance: Detection, prevention, and management

Frontiers in Medicine, 2022
Naveen Kumar Devanga Ragupathi, Naveen Kumar Devanga Ragupathi, Naveen Kumar Devanga Ragupathi, Naveen Kumar Devanga Ragupathi, Balaji Veeraraghavan, Balaji Veeraraghavan, Esther Karunakaran, Esther Karunakaran, Esther Karunakaran, Peter N. Monk, Peter N. Monk   +10 more
doaj   +1 more source

Combined Complementary and Alternative Therapies for the Management of a Breech Fetus: A Feasibility Study. [PDF]

AJP Rep
Babbar S, Williams KB, Vawter L.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Organoid-based two-step drug screening for rapid identification of chemotherapy-resistant oesophageal squamous cell carcinoma and alternative therapies. [PDF]

Clin Transl Med
Shao CY, Ju S, Tong X, Hu K, Li Y, Zhu YX, Yang J, Li C, Xie YF, Cui Y, Deng WJ, Ding C, Qin SB, Zhao J.   +13 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Alternative Therapies for Non-Motor Symptoms in Parkinson's Disease: A Mini Review. [PDF]

Neuropsychiatr Dis Treat
Liu H, Wang XP.
europepmc   +1 more source